Antiplatelet Effect of Catechol Is Related to Inhibition of Cyclooxygenase, Reactive Oxygen Species, ERK/p38 Signaling and Thromboxane A2 Production

Mei-Chi Chang; Hsiao-Hua Chang; Tong-Mei Wang; Chiu-Po Chan; Bor-Ru Lin; Sin-Yuet Yeung; Chien-Yang Yeh; Ru-Hsiu Cheng; Jiiang-Huei Jeng

doi:10.1371/journal.pone.0104310

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Open Access

Peer-reviewed

Research Article

Antiplatelet Effect of Catechol Is Related to Inhibition of Cyclooxygenase, Reactive Oxygen Species, ERK/p38 Signaling and Thromboxane A₂ Production

Mei-Chi Chang ,

Contributed equally to this work with: Mei-Chi Chang, Hsiao-Hua Chang, Chiu-Po Chan

Affiliation Biomedical Science Team, Chang Gung University of Science and Technology, Taoyuan,Taiwan
⨯
Hsiao-Hua Chang ,

Contributed equally to this work with: Mei-Chi Chang, Hsiao-Hua Chang, Chiu-Po Chan

Affiliation Laboratory of Pharmacology & Toxicology, Graduate Institute of Clinical Dentistry and Department of Dentistry, National Taiwan University Hospital and National Taiwan University Medical College, Taipei, Taiwan
⨯
Tong-Mei Wang,

Affiliation Laboratory of Pharmacology & Toxicology, Graduate Institute of Clinical Dentistry and Department of Dentistry, National Taiwan University Hospital and National Taiwan University Medical College, Taipei, Taiwan
⨯
Chiu-Po Chan ,

Contributed equally to this work with: Mei-Chi Chang, Hsiao-Hua Chang, Chiu-Po Chan

Affiliation Department of Dentistry, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
⨯
Bor-Ru Lin,

Affiliation Department of Diagnotherapeutics, National Taiwan University Hospital, Taipei, Taiwan
⨯
Sin-Yuet Yeung,

Affiliation Department of Dentistry, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
⨯
Chien-Yang Yeh,

Affiliation Laboratory of Pharmacology & Toxicology, Graduate Institute of Clinical Dentistry and Department of Dentistry, National Taiwan University Hospital and National Taiwan University Medical College, Taipei, Taiwan
⨯
Ru-Hsiu Cheng,

Affiliation Biomedical Science Team, Chang Gung University of Science and Technology, Taoyuan,Taiwan
⨯
Jiiang-Huei Jeng

* E-mail: jhjeng@ntu.edu.tw

Affiliation Laboratory of Pharmacology & Toxicology, Graduate Institute of Clinical Dentistry and Department of Dentistry, National Taiwan University Hospital and National Taiwan University Medical College, Taipei, Taiwan
⨯

Antiplatelet Effect of Catechol Is Related to Inhibition of Cyclooxygenase, Reactive Oxygen Species, ERK/p38 Signaling and Thromboxane A₂ Production

Mei-Chi Chang,
Hsiao-Hua Chang,
Tong-Mei Wang,
Chiu-Po Chan,
Bor-Ru Lin,
Sin-Yuet Yeung,
Chien-Yang Yeh,
Ru-Hsiu Cheng,
Jiiang-Huei Jeng

Published: August 14, 2014
https://doi.org/10.1371/journal.pone.0104310

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COX-2 inhibitors
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