Chemotherapy-Induced Monoamine Oxidase Expression in Prostate Carcinoma Functions as a Cytoprotective Resistance Enzyme and Associates with Clinical Outcomes

Ryan R. Gordon; Mengchu Wu; Chung-Ying Huang; William P. Harris; Hong Gee Sim; Jared M. Lucas; Ilsa Coleman; Celestia S. Higano; Roman Gulati; Lawrence D. True; Robert Vessella; Paul H. Lange; Mark Garzotto; Tomasz M. Beer; Peter S. Nelson

doi:10.1371/journal.pone.0104271

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Peer-reviewed

Research Article

Chemotherapy-Induced Monoamine Oxidase Expression in Prostate Carcinoma Functions as a Cytoprotective Resistance Enzyme and Associates with Clinical Outcomes

Ryan R. Gordon ,

Contributed equally to this work with: Ryan R. Gordon, Mengchu Wu

Affiliation Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Mengchu Wu ,

Contributed equally to this work with: Ryan R. Gordon, Mengchu Wu

Affiliation Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Chung-Ying Huang,

Affiliation Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
William P. Harris,

Affiliation Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Hong Gee Sim,

Affiliation Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Jared M. Lucas,

Affiliation Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Ilsa Coleman,

Affiliation Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Celestia S. Higano,

Affiliations Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Urology, University of Washington, Seattle, Washington, United States of America
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Roman Gulati,

Affiliation Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Lawrence D. True,

Affiliations Department of Pathology, University of Washington, Seattle, Washington, United States of America, Department of Urology, University of Washington, Seattle, Washington, United States of America
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Robert Vessella,

Affiliation Department of Urology, University of Washington, Seattle, Washington, United States of America
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Paul H. Lange,

Affiliation Department of Urology, University of Washington, Seattle, Washington, United States of America
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Mark Garzotto,

Affiliations Department of Urology and Cancer Institute, Oregon Health and Sciences University, Portland, Oregon, United States of America, Section of Urology, Portland VA Medical Center, Portland, Oregon, United States of America
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Tomasz M. Beer,

Affiliation Department of Medicine, Oregon Health and Sciences University, Portland, Oregon, United States of America
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Peter S. Nelson

* E-mail: pnelson@fhcrc.org

Affiliations Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Pathology, University of Washington, Seattle, Washington, United States of America, Department of Urology, University of Washington, Seattle, Washington, United States of America
⨯

Chemotherapy-Induced Monoamine Oxidase Expression in Prostate Carcinoma Functions as a Cytoprotective Resistance Enzyme and Associates with Clinical Outcomes

Ryan R. Gordon,
Mengchu Wu,
Chung-Ying Huang,
William P. Harris,
Hong Gee Sim,
Jared M. Lucas,
Ilsa Coleman,
Celestia S. Higano,
Roman Gulati,
Lawrence D. True

Published: September 8, 2014
https://doi.org/10.1371/journal.pone.0104271

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Reactive oxygen species
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