Phosphorylation Site Dynamics of Early T-cell Receptor Signaling

Lily A. Chylek; Vyacheslav Akimov; Jörn Dengjel; Kristoffer T. G. Rigbolt; Bin Hu; William S. Hlavacek; Blagoy Blagoev

doi:10.1371/journal.pone.0104240

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Open Access

Peer-reviewed

Research Article

Phosphorylation Site Dynamics of Early T-cell Receptor Signaling

Lily A. Chylek ,

Contributed equally to this work with: Lily A. Chylek, Vyacheslav Akimov, Jörn Dengjel

Affiliations Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, United States of America
⨯
Vyacheslav Akimov ,

Contributed equally to this work with: Lily A. Chylek, Vyacheslav Akimov, Jörn Dengjel

Affiliation Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
⨯
Jörn Dengjel ,

Contributed equally to this work with: Lily A. Chylek, Vyacheslav Akimov, Jörn Dengjel

Affiliation Department of Dermatology, Medical Center; Freiburg Institute for Advanced Studies (FRIAS); BIOSS Centre for Biological Signalling Studies; ZBSA Center for Biological Systems Analysis, University of Freiburg, Freiburg, Germany
⨯
Kristoffer T. G. Rigbolt,

Current address: Gubra, Hørsholm, Denmark

Affiliation Department of Dermatology, Medical Center; Freiburg Institute for Advanced Studies (FRIAS); BIOSS Centre for Biological Signalling Studies; ZBSA Center for Biological Systems Analysis, University of Freiburg, Freiburg, Germany
⨯
Bin Hu,

Current address: SRA International, Atlanta, Georgia, United States of America

Affiliations Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, Department of Biology, University of New Mexico, Albuquerque, New Mexico, United States of America
⨯
William S. Hlavacek ,

* E-mail: wish@lanl.gov (WSH); bab@bmb.sdu.dk (BB)

Affiliations Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, Department of Biology, University of New Mexico, Albuquerque, New Mexico, United States of America
⨯
Blagoy Blagoev

* E-mail: wish@lanl.gov (WSH); bab@bmb.sdu.dk (BB)

Affiliation Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
⨯

Phosphorylation Site Dynamics of Early T-cell Receptor Signaling

Lily A. Chylek,
Vyacheslav Akimov,
Jörn Dengjel,
Kristoffer T. G. Rigbolt,
Bin Hu,
William S. Hlavacek,
Blagoy Blagoev

Published: August 22, 2014
https://doi.org/10.1371/journal.pone.0104240

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Phosphorylation
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TCR signaling cascade
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T cell receptors
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T cells
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Immunoprecipitation
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Immunoblotting
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Phosphatases
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Tyrosine
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