Mycobacterium Avium subsp. Paratuberculosis Isolates Induce In Vitro Granuloma Formation and Show Successful Survival Phenotype, Common Anti-Inflammatory and Antiapoptotic Responses within Ovine Macrophages Regardless of Genotype or Host of Origin

Naiara Abendaño; Lyudmila Tyukalova; Jesse F. Barandika; Ana Balseiro; Iker A. Sevilla; Joseba M. Garrido; Ramon A. Juste; Marta Alonso-Hearn

doi:10.1371/journal.pone.0104238

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Research Article

Mycobacterium Avium subsp. Paratuberculosis Isolates Induce In Vitro Granuloma Formation and Show Successful Survival Phenotype, Common Anti-Inflammatory and Antiapoptotic Responses within Ovine Macrophages Regardless of Genotype or Host of Origin

Naiara Abendaño,

Affiliation Department of Animal Health, Basque Institute for Agricultural Research and Development, NEIKER-Tecnalia, Technological Park of Bizkaia, Bizkaia, Spain
⨯
Lyudmila Tyukalova,

Affiliation Department of Animal Health, Basque Institute for Agricultural Research and Development, NEIKER-Tecnalia, Technological Park of Bizkaia, Bizkaia, Spain
⨯
Jesse F. Barandika,

Affiliation Department of Animal Health, Basque Institute for Agricultural Research and Development, NEIKER-Tecnalia, Technological Park of Bizkaia, Bizkaia, Spain
⨯
Ana Balseiro,

Affiliation Department of Animal Health, Department of Agriculture of the Regional Government of the Principality of Asturias, SERIDA, Deva, Asturias, Spain
⨯
Iker A. Sevilla,

Affiliation Department of Animal Health, Basque Institute for Agricultural Research and Development, NEIKER-Tecnalia, Technological Park of Bizkaia, Bizkaia, Spain
⨯
Joseba M. Garrido,

Affiliation Department of Animal Health, Basque Institute for Agricultural Research and Development, NEIKER-Tecnalia, Technological Park of Bizkaia, Bizkaia, Spain
⨯
Ramon A. Juste,

Affiliation Department of Animal Health, Basque Institute for Agricultural Research and Development, NEIKER-Tecnalia, Technological Park of Bizkaia, Bizkaia, Spain
⨯
Marta Alonso-Hearn

* E-mail: malonso@neiker

Affiliation Department of Animal Health, Basque Institute for Agricultural Research and Development, NEIKER-Tecnalia, Technological Park of Bizkaia, Bizkaia, Spain
⨯

Mycobacterium Avium subsp. Paratuberculosis Isolates Induce In Vitro Granuloma Formation and Show Successful Survival Phenotype, Common Anti-Inflammatory and Antiapoptotic Responses within Ovine Macrophages Regardless of Genotype or Host of Origin

Naiara Abendaño,
Lyudmila Tyukalova,
Jesse F. Barandika,
Ana Balseiro,
Iker A. Sevilla,
Joseba M. Garrido,
Ramon A. Juste,
Marta Alonso-Hearn

Published: August 11, 2014
https://doi.org/10.1371/journal.pone.0104238

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