Early Skewed Distribution of Total and HIV-Specific CD8+ T-Cell Memory Phenotypes during Primary HIV Infection Is Related to Reduced Antiviral Activity and Faster Disease Progression

Yanina Ghiglione; Juliana Falivene; María Julia Ruiz; Natalia Laufer; María Eugenia Socías; Pedro Cahn; Luis Giavedoni; Omar Sued; María Magdalena Gherardi; Horacio Salomón; Gabriela Turk

doi:10.1371/journal.pone.0104235

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Open Access

Peer-reviewed

Research Article

Early Skewed Distribution of Total and HIV-Specific CD8⁺ T-Cell Memory Phenotypes during Primary HIV Infection Is Related to Reduced Antiviral Activity and Faster Disease Progression

Yanina Ghiglione,

Affiliation Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires- CONICET, Buenos Aires, Argentina
⨯
Juliana Falivene,

Affiliation Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires- CONICET, Buenos Aires, Argentina
⨯
María Julia Ruiz,

Affiliation Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires- CONICET, Buenos Aires, Argentina
⨯
Natalia Laufer,

Affiliations Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires- CONICET, Buenos Aires, Argentina, Hospital J.A. Fernández, Buenos Aires, Argentina
⨯
María Eugenia Socías,

Affiliations Fundación Huésped, Buenos Aires, Argentina, Hospital J.A. Fernández, Buenos Aires, Argentina
⨯
Pedro Cahn,

Affiliations Fundación Huésped, Buenos Aires, Argentina, Hospital J.A. Fernández, Buenos Aires, Argentina
⨯
Luis Giavedoni,

Affiliation Department of Virology and Immunology, Southwest National Primate Research Center, Texas Biomedical, Research Institute, San Antonio, Texas, United States of America
⨯
Omar Sued,

Affiliations Fundación Huésped, Buenos Aires, Argentina, Hospital J.A. Fernández, Buenos Aires, Argentina
⨯
María Magdalena Gherardi,

Affiliation Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires- CONICET, Buenos Aires, Argentina
⨯
Horacio Salomón,

Affiliation Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires- CONICET, Buenos Aires, Argentina
⨯
Gabriela Turk

* E-mail: gturk@fmed.uba.ar

Affiliation Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires- CONICET, Buenos Aires, Argentina
⨯

Early Skewed Distribution of Total and HIV-Specific CD8⁺ T-Cell Memory Phenotypes during Primary HIV Infection Is Related to Reduced Antiviral Activity and Faster Disease Progression

Yanina Ghiglione,
Juliana Falivene,
María Julia Ruiz,
Natalia Laufer,
María Eugenia Socías,
Pedro Cahn,
Luis Giavedoni,
Omar Sued,
María Magdalena Gherardi,
Horacio Salomón

Published: August 5, 2014
https://doi.org/10.1371/journal.pone.0104235

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HIV infections
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Cell differentiation
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HIV
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