A High Throughput Screen Identifies Potent and Selective Inhibitors to Human Epithelial 15-Lipoxygenase-2

J. Brian Jameson II; Auric Kantz; Lena Schultz; Chakrapani Kalyanaraman; Matthew P. Jacobson; David J. Maloney; Ajit Jadhav; Anton Simeonov; Theodore R. Holman

doi:10.1371/journal.pone.0104094

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Peer-reviewed

Research Article

A High Throughput Screen Identifies Potent and Selective Inhibitors to Human Epithelial 15-Lipoxygenase-2

J. Brian Jameson II,

Affiliation Chemistry and Biochemistry Department, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Auric Kantz,

Affiliation Chemistry and Biochemistry Department, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Lena Schultz,

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Chakrapani Kalyanaraman,

Affiliation Department of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco, San Francisco, California, United States of America
⨯
Matthew P. Jacobson,

Affiliation Department of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco, San Francisco, California, United States of America
⨯
David J. Maloney,

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ajit Jadhav,

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Anton Simeonov ,

* E-mail: asimeono@mail.nih.gov (AS); tholman@chemistry.ucsc.edu (TRH)

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Theodore R. Holman

* E-mail: asimeono@mail.nih.gov (AS); tholman@chemistry.ucsc.edu (TRH)

Affiliation Chemistry and Biochemistry Department, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯

A High Throughput Screen Identifies Potent and Selective Inhibitors to Human Epithelial 15-Lipoxygenase-2

J. Brian Jameson II,
Auric Kantz,
Lena Schultz,
Chakrapani Kalyanaraman,
Matthew P. Jacobson,
David J. Maloney,
Ajit Jadhav,
Anton Simeonov,
Theodore R. Holman

Published: August 11, 2014
https://doi.org/10.1371/journal.pone.0104094

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