HIV-Derived ssRNA Binds to TLR8 to Induce Inflammation-Driven Macrophage Foam Cell Formation

Mark A. Bernard; Xinbing Han; Sonya Inderbitzin; Ifunanya Agbim; Hui Zhao; Henry Koziel; Souvenir D. Tachado

doi:10.1371/journal.pone.0104039

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Peer-reviewed

Research Article

HIV-Derived ssRNA Binds to TLR8 to Induce Inflammation-Driven Macrophage Foam Cell Formation

Mark A. Bernard,

Affiliation Division of Pulmonary, Critical Care, and Sleep Medicine; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Xinbing Han,

Current address: Children’s Hospital, Boston, Massachusetts, United States of America

Affiliation Division of Pulmonary, Critical Care, and Sleep Medicine; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Sonya Inderbitzin,

Affiliation Division of Pulmonary, Critical Care, and Sleep Medicine; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Ifunanya Agbim,

Affiliation Division of Pulmonary, Critical Care, and Sleep Medicine; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Hui Zhao,

Affiliations Division of Pulmonary, Critical Care, and Sleep Medicine; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, From Department of Respiratory Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, PR China
⨯
Henry Koziel,

Affiliation Division of Pulmonary, Critical Care, and Sleep Medicine; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Souvenir D. Tachado

* E-mail: stachado@bidmc.harvard.edu

Affiliation Division of Pulmonary, Critical Care, and Sleep Medicine; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
⨯

HIV-Derived ssRNA Binds to TLR8 to Induce Inflammation-Driven Macrophage Foam Cell Formation

Mark A. Bernard,
Xinbing Han,
Sonya Inderbitzin,
Ifunanya Agbim,
Hui Zhao,
Henry Koziel,
Souvenir D. Tachado

Published: August 4, 2014
https://doi.org/10.1371/journal.pone.0104039

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HIV
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Fluorescence resonance energy transfer
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Inflammation
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