Human CD56+ Cytotoxic Lung Lymphocytes Kill Autologous Lung Cells in Chronic Obstructive Pulmonary Disease

Christine M. Freeman; Valerie R. Stolberg; Sean Crudgington; Fernando J. Martinez; MeiLan K. Han; Stephen W. Chensue; Douglas A. Arenberg; Catherine A. Meldrum; Lisa McCloskey; Jeffrey L. Curtis

doi:10.1371/journal.pone.0103840

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Open Access

Peer-reviewed

Research Article

Human CD56+ Cytotoxic Lung Lymphocytes Kill Autologous Lung Cells in Chronic Obstructive Pulmonary Disease

Christine M. Freeman ,

* E-mail: cmfreema@umich.edu

Affiliations Research Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, United States of America, Pulmonary & Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America
⨯
Valerie R. Stolberg,

Affiliation Research Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, United States of America
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Sean Crudgington,

Affiliation Pulmonary & Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America
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Fernando J. Martinez,

Affiliation Pulmonary & Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America
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MeiLan K. Han,

Affiliation Pulmonary & Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America
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Stephen W. Chensue,

Affiliations Graduate Program in Immunology, University of Michigan, Ann Arbor, Michigan, United States of America, Pathology & Laboratory Medicine Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, United States of America, Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan, United States of America
⨯
Douglas A. Arenberg,

Affiliation Pulmonary & Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America
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Catherine A. Meldrum,

Affiliation Pulmonary & Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America
⨯
Lisa McCloskey,

Affiliation Pulmonary & Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America
⨯
Jeffrey L. Curtis

Affiliations Pulmonary & Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America, Graduate Program in Immunology, University of Michigan, Ann Arbor, Michigan, United States of America, Pulmonary & Critical Care Medicine Section, Medicine Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, United States of America
⨯

Human CD56+ Cytotoxic Lung Lymphocytes Kill Autologous Lung Cells in Chronic Obstructive Pulmonary Disease

Christine M. Freeman,
Valerie R. Stolberg,
Sean Crudgington,
Fernando J. Martinez,
MeiLan K. Han,
Stephen W. Chensue,
Douglas A. Arenberg,
Catherine A. Meldrum,
Lisa McCloskey,
Jeffrey L. Curtis

Published: July 31, 2014
https://doi.org/10.1371/journal.pone.0103840

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Chronic obstructive pulmonary disease
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NK cells
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T cells
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Cytotoxic T cells
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Cytotoxicity
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Cell staining
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Epithelial cells
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