Lactate and Choline Metabolites Detected In Vitro by Nuclear Magnetic Resonance Spectroscopy Are Potential Metabolic Biomarkers for PI3K Inhibition in Pediatric Glioblastoma

Nada M. S. Al-Saffar; Lynley V. Marshall; L. Elizabeth Jackson; Geetha Balarajah; Thomas R. Eykyn; Alice Agliano; Paul A. Clarke; Chris Jones; Paul Workman; Andrew D. J. Pearson; Martin O. Leach

doi:10.1371/journal.pone.0103835

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Open Access

Peer-reviewed

Research Article

Lactate and Choline Metabolites Detected In Vitro by Nuclear Magnetic Resonance Spectroscopy Are Potential Metabolic Biomarkers for PI3K Inhibition in Pediatric Glioblastoma

Nada M. S. Al-Saffar ,

* E-mail: Nada.Al-Saffar@icr.ac.uk

Affiliation Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Lynley V. Marshall,

Affiliations Division of Molecular Pathology, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, Division of Cancer Therapeutics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, Division of Clinical Studies. The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
L. Elizabeth Jackson,

Affiliation Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Geetha Balarajah,

Current address: Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom

Affiliation Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Thomas R. Eykyn,

Affiliations Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, Division of Imaging Sciences and Biomedical Engineering, King’s College London, St Thomas’ Hospital, London, United Kingdom
⨯
Alice Agliano,

Affiliation Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Paul A. Clarke,

Affiliations Division of Cancer Therapeutics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom
⨯
Chris Jones,

Affiliations Division of Molecular Pathology, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, Division of Cancer Therapeutics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Paul Workman,

Affiliations Division of Cancer Therapeutics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom
⨯
Andrew D. J. Pearson,

Affiliations Division of Cancer Therapeutics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, Division of Clinical Studies. The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Martin O. Leach

Affiliation Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯

Lactate and Choline Metabolites Detected In Vitro by Nuclear Magnetic Resonance Spectroscopy Are Potential Metabolic Biomarkers for PI3K Inhibition in Pediatric Glioblastoma

Nada M. S. Al-Saffar,
Lynley V. Marshall,
L. Elizabeth Jackson,
Geetha Balarajah,
Thomas R. Eykyn,
Alice Agliano,
Paul A. Clarke,
Chris Jones,
Paul Workman,
Andrew D. J. Pearson

Published: August 1, 2014
https://doi.org/10.1371/journal.pone.0103835

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