The “Gate Keeper” Role of Trp222 Determines the Enantiopreference of Diketoreductase toward 2-Chloro-1-Phenylethanone

Open Access

Peer-reviewed

Research Article

Hairong Ma ,

Contributed equally to this work with: Hairong Ma, Xin Yang

Affiliation State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, Nanjing, Jiangsu Province, People's Republic of China
⨯
Xin Yang ,

Contributed equally to this work with: Hairong Ma, Xin Yang

Affiliation State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, Nanjing, Jiangsu Province, People's Republic of China
⨯
Zhuo Lu,

Affiliation State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, Nanjing, Jiangsu Province, People's Republic of China
⨯
Nan Liu,

Affiliation State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, Nanjing, Jiangsu Province, People's Republic of China
⨯
Yijun Chen

* E-mail: yjchen@cpu.edu

Affiliation State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, Nanjing, Jiangsu Province, People's Republic of China
⨯

Reader Comments (0)

Alcohols
Is the Subject Area "Alcohols" applicable to this article?

Thanks for your feedback.
Amino acid substitution
Is the Subject Area "Amino acid substitution" applicable to this article?

Thanks for your feedback.
Amino acid analysis
Is the Subject Area "Amino acid analysis" applicable to this article?

Thanks for your feedback.
Enzymes
Is the Subject Area "Enzymes" applicable to this article?

Thanks for your feedback.
Ketones
Is the Subject Area "Ketones" applicable to this article?

Thanks for your feedback.
Plasmid construction
Is the Subject Area "Plasmid construction" applicable to this article?

Thanks for your feedback.
Transfer RNA
Is the Subject Area "Transfer RNA" applicable to this article?

Thanks for your feedback.
Enantiomers
Is the Subject Area "Enantiomers" applicable to this article?

Thanks for your feedback.