MALT1 Auto-Proteolysis Is Essential for NF-κB-Dependent Gene Transcription in Activated Lymphocytes

Mathijs Baens; Luca Bonsignore; Riet Somers; Charlotte Vanderheydt; Stephen D. Weeks; Jenny Gunnarsson; Ewa Nilsson; Robert G. Roth; Margot Thome; Peter Marynen

doi:10.1371/journal.pone.0103774

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Open Access

Peer-reviewed

Research Article

MALT1 Auto-Proteolysis Is Essential for NF-κB-Dependent Gene Transcription in Activated Lymphocytes

Mathijs Baens ,

* E-mail: thijs.baens@med.kuleuven.be

Affiliations Human Genome Laboratory, VIB Center for the Biology of Disease, Leuven, Belgium, Human Genome Laboratory, Center for Human Genetics, KU Leuven, Leuven, Belgium
⨯
Luca Bonsignore,

Affiliation Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
⨯
Riet Somers,

Affiliations Human Genome Laboratory, VIB Center for the Biology of Disease, Leuven, Belgium, Human Genome Laboratory, Center for Human Genetics, KU Leuven, Leuven, Belgium
⨯
Charlotte Vanderheydt,

Affiliations Human Genome Laboratory, VIB Center for the Biology of Disease, Leuven, Belgium, Human Genome Laboratory, Center for Human Genetics, KU Leuven, Leuven, Belgium
⨯
Stephen D. Weeks,

Affiliation Laboratory for Biocrystallography, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium
⨯
Jenny Gunnarsson,

Affiliation Reagent and Assay Development, Discovery Sciences, Innovative Medicines, AstraZeneca R&D, Mölndal, Sweden
⨯
Ewa Nilsson,

Affiliation Reagent and Assay Development, Discovery Sciences, Innovative Medicines, AstraZeneca R&D, Mölndal, Sweden
⨯
Robert G. Roth,

Affiliation Reagent and Assay Development, Discovery Sciences, Innovative Medicines, AstraZeneca R&D, Mölndal, Sweden
⨯
Margot Thome,

Affiliation Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
⨯
Peter Marynen

Affiliation Human Genome Laboratory, Center for Human Genetics, KU Leuven, Leuven, Belgium
⨯

MALT1 Auto-Proteolysis Is Essential for NF-κB-Dependent Gene Transcription in Activated Lymphocytes

Mathijs Baens,
Luca Bonsignore,
Riet Somers,
Charlotte Vanderheydt,
Stephen D. Weeks,
Jenny Gunnarsson,
Ewa Nilsson,
Robert G. Roth,
Margot Thome,
Peter Marynen

Published: August 8, 2014
https://doi.org/10.1371/journal.pone.0103774

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