Gene Expression Analysis Suggests Bone Development-Related Genes GDF5 and DIO2 Are Involved in the Development of Kashin-Beck Disease in Children Rather than Adults

Yan Wen; Feng Zhang; Chunyan Li; Shulan He; Wuhong Tan; Yanxia Lei; Qiang Zhang; Hanjie Yu; Jingjing Zheng; Xiong Guo

doi:10.1371/journal.pone.0103618

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Peer-reviewed

Research Article

Gene Expression Analysis Suggests Bone Development-Related Genes GDF5 and DIO2 Are Involved in the Development of Kashin-Beck Disease in Children Rather than Adults

Yan Wen,

Affiliation School of Public Health, Health Science Center, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry Health, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China
⨯
Feng Zhang,

Affiliation School of Public Health, Health Science Center, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry Health, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China
⨯
Chunyan Li,

Affiliation School of Public Health, Health Science Center, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry Health, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China
⨯
Shulan He,

Affiliation School of Public Health, Health Science Center, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry Health, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China
⨯
Wuhong Tan,

Affiliation School of Public Health, Health Science Center, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry Health, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China
⨯
Yanxia Lei,

Affiliation School of Public Health, Health Science Center, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry Health, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China
⨯
Qiang Zhang,

Affiliation Department of Kashin-Beck Diseases, Qinghai Institute for Endemic Disease Control and Prevention, Xining, Qinghai, P. R. China
⨯
Hanjie Yu,

Affiliation National Engineering Research Center for Miniaturized Detection Systems, Northwest University, Xi'an, Shaanxi, P. R. China
⨯
Jingjing Zheng,

Affiliation School of Public Health, Health Science Center, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry Health, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China
⨯
Xiong Guo

* E-mail: guox@mail.xjtu.edu.cn

Affiliation School of Public Health, Health Science Center, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry Health, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China
⨯

Gene Expression Analysis Suggests Bone Development-Related Genes GDF5 and DIO2 Are Involved in the Development of Kashin-Beck Disease in Children Rather than Adults

Yan Wen,
Feng Zhang,
Chunyan Li,
Shulan He,
Wuhong Tan,
Yanxia Lei,
Qiang Zhang,
Hanjie Yu,
Jingjing Zheng,
Xiong Guo

Published: July 29, 2014
https://doi.org/10.1371/journal.pone.0103618

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