Hypoxia Preconditioned Mesenchymal Stem Cells Prevent Cardiac Fibroblast Activation and Collagen Production via Leptin

Panpan Chen; Rongrong Wu; Wei Zhu; Zhi Jiang; Yinchuan Xu; Han Chen; Zhaocai Zhang; Huiqiang Chen; Ling Zhang; Hong Yu; Jian'an Wang; Xinyang Hu

doi:10.1371/journal.pone.0103587

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Peer-reviewed

Research Article

Hypoxia Preconditioned Mesenchymal Stem Cells Prevent Cardiac Fibroblast Activation and Collagen Production via Leptin

Panpan Chen,

Affiliations Division of Cardiology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, Hangzhou, China, Provincial Key Laboratory of Cardiovascular Research, Zhejiang Province, Hangzhou, China
⨯
Rongrong Wu,

Affiliations Division of Cardiology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, Hangzhou, China, Provincial Key Laboratory of Cardiovascular Research, Zhejiang Province, Hangzhou, China
⨯
Wei Zhu,

Affiliations Division of Cardiology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, Hangzhou, China, Provincial Key Laboratory of Cardiovascular Research, Zhejiang Province, Hangzhou, China
⨯
Zhi Jiang,

Affiliations Division of Cardiology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, Hangzhou, China, Provincial Key Laboratory of Cardiovascular Research, Zhejiang Province, Hangzhou, China
⨯
Yinchuan Xu,

Affiliations Division of Cardiology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, Hangzhou, China, Provincial Key Laboratory of Cardiovascular Research, Zhejiang Province, Hangzhou, China
⨯
Han Chen,

Affiliations Division of Cardiology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, Hangzhou, China, Provincial Key Laboratory of Cardiovascular Research, Zhejiang Province, Hangzhou, China
⨯
Zhaocai Zhang,

Affiliations Division of Cardiology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, Hangzhou, China, Provincial Key Laboratory of Cardiovascular Research, Zhejiang Province, Hangzhou, China
⨯
Huiqiang Chen,

Affiliations Division of Cardiology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, Hangzhou, China, Provincial Key Laboratory of Cardiovascular Research, Zhejiang Province, Hangzhou, China
⨯
Ling Zhang,

Affiliations Division of Cardiology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, Hangzhou, China, Provincial Key Laboratory of Cardiovascular Research, Zhejiang Province, Hangzhou, China
⨯
Hong Yu,

Affiliations Division of Cardiology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, Hangzhou, China, Provincial Key Laboratory of Cardiovascular Research, Zhejiang Province, Hangzhou, China
⨯
Jian'an Wang ,

* E-mail: hxy0507@hotmail.com (XH); Jian_an_wang@yahoo.com (JW)

Affiliations Division of Cardiology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, Hangzhou, China, Provincial Key Laboratory of Cardiovascular Research, Zhejiang Province, Hangzhou, China
⨯
Xinyang Hu

* E-mail: hxy0507@hotmail.com (XH); Jian_an_wang@yahoo.com (JW)

Affiliations Division of Cardiology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, Hangzhou, China, Provincial Key Laboratory of Cardiovascular Research, Zhejiang Province, Hangzhou, China
⨯

Hypoxia Preconditioned Mesenchymal Stem Cells Prevent Cardiac Fibroblast Activation and Collagen Production via Leptin

Panpan Chen,
Rongrong Wu,
Wei Zhu,
Zhi Jiang,
Yinchuan Xu,
Han Chen,
Zhaocai Zhang,
Huiqiang Chen,
Ling Zhang,
Hong Yu

Published: August 12, 2014
https://doi.org/10.1371/journal.pone.0103587

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Fibroblasts
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Leptin
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Hypoxia
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Immunofluorescence staining
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Myocardial infarction
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