Activated cMET and IGF1R-Driven PI3K Signaling Predicts Poor Survival in Colorectal Cancers Independent of KRAS Mutational Status

Jeeyun Lee; Anjali Jain; Phillip Kim; Tani Lee; Anne Kuller; Fred Princen; In-Gu; Suk Hyeong Kim; Joon Oh Park; Young Suk Park; Sharat Singh; Hee Cheol Kim

doi:10.1371/journal.pone.0103551

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Open Access

Peer-reviewed

Research Article

Activated cMET and IGF1R-Driven PI3K Signaling Predicts Poor Survival in Colorectal Cancers Independent of KRAS Mutational Status

Jeeyun Lee ,

Contributed equally to this work with: Jeeyun Lee, Anjali Jain, Phillip Kim

Affiliation Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Anjali Jain ,

Contributed equally to this work with: Jeeyun Lee, Anjali Jain, Phillip Kim

Affiliation Research and Development, Oncology, Prometheus Laboratories, San Diego, California, United States of America
⨯
Phillip Kim ,

Contributed equally to this work with: Jeeyun Lee, Anjali Jain, Phillip Kim

Affiliation Research and Development, Oncology, Prometheus Laboratories, San Diego, California, United States of America
⨯
Tani Lee,

Affiliation Research and Development, Oncology, Prometheus Laboratories, San Diego, California, United States of America
⨯
Anne Kuller,

Affiliation Research and Development, Oncology, Prometheus Laboratories, San Diego, California, United States of America
⨯
Fred Princen,

Affiliation Research and Development, Oncology, Prometheus Laboratories, San Diego, California, United States of America
⨯
In-Gu,

Affiliation Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Suk Hyeong Kim,

Affiliation Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Joon Oh Park,

Affiliation Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Young Suk Park,

Affiliation Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Sharat Singh,

Affiliation Research and Development, Oncology, Prometheus Laboratories, San Diego, California, United States of America
⨯
Hee Cheol Kim

* E-mail: hckim@skku.edu

Affiliation Departments of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯

Activated cMET and IGF1R-Driven PI3K Signaling Predicts Poor Survival in Colorectal Cancers Independent of KRAS Mutational Status

Jeeyun Lee,
Anjali Jain,
Phillip Kim,
Tani Lee,
Anne Kuller,
Fred Princen,
In-Gu,
Suk Hyeong Kim,
Joon Oh Park,
Young Suk Park

Published: August 4, 2014
https://doi.org/10.1371/journal.pone.0103551

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