Mitochondria-Targeted Catalase Reverts the Neurotoxicity of hSOD1G93A Astrocytes without Extending the Survival of ALS-Linked Mutant hSOD1 Mice

Open Access

Peer-reviewed

Research Article

Mitochondria-Targeted Catalase Reverts the Neurotoxicity of hSOD1^G93A Astrocytes without Extending the Survival of ALS-Linked Mutant hSOD1 Mice

Mariana Pehar,

Affiliation Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina, United States of America
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Gyda Beeson,

Affiliation SCCP Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America
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Craig C. Beeson,

Affiliation SCCP Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America
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Jeffrey A. Johnson,

Affiliation Division of Pharmaceutical Sciences, Waisman Center, Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin, United States of America
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Marcelo R. Vargas

* E-mail: vargasm@musc.edu

Affiliation Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina, United States of America
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Mitochondria
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Astrocytes
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Catalases
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Motor neurons
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Amyotrophic lateral sclerosis
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Genetically modified animals
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Toxicity
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Spinal cord
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