Proteasome Inhibitors Activate Autophagy Involving Inhibition of PI3K-Akt-mTOR Pathway as an Anti-Oxidation Defense in Human RPE Cells

Bingrong Tang; Jingjing Cai; Lin Sun; Yiping Li; Jia Qu; Barbara Joy Snider; Shengzhou Wu

doi:10.1371/journal.pone.0103364

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Peer-reviewed

Research Article

Proteasome Inhibitors Activate Autophagy Involving Inhibition of PI3K-Akt-mTOR Pathway as an Anti-Oxidation Defense in Human RPE Cells

Bingrong Tang ,

Contributed equally to this work with: Bingrong Tang, Jingjing Cai

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, P.R. China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang Province, P.R. China
⨯
Jingjing Cai ,

Contributed equally to this work with: Bingrong Tang, Jingjing Cai

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, P.R. China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang Province, P.R. China
⨯
Lin Sun,

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, P.R. China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang Province, P.R. China
⨯
Yiping Li,

Affiliation Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China
⨯
Jia Qu,

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, P.R. China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang Province, P.R. China
⨯
Barbara Joy Snider,

Affiliation Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Shengzhou Wu

* E-mail: wszlab@mail.eye.ac.cn

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, P.R. China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang Province, P.R. China
⨯

Proteasome Inhibitors Activate Autophagy Involving Inhibition of PI3K-Akt-mTOR Pathway as an Anti-Oxidation Defense in Human RPE Cells

Bingrong Tang,
Jingjing Cai,
Lin Sun,
Yiping Li,
Jia Qu,
Barbara Joy Snider,
Shengzhou Wu

Published: July 25, 2014
https://doi.org/10.1371/journal.pone.0103364

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Autophagic cell death
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Proteasomes
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MTS assay
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