Silencing of Hypoxia-Inducible Factor-1β Induces Anti-Tumor Effects in Hepatoma Cell Lines under Tumor Hypoxia

Sung Hoon Choi; Ae Ri Chung; Wonseok Kang; Jun Yong Park; Mi Sol Lee; Shin Won Hwang; Do Young Kim; Seung Up Kim; Sang Hoon Ahn; Seungtaek Kim; Kwang-Hyub Han

doi:10.1371/journal.pone.0103304

Loading metrics

Open Access

Peer-reviewed

Research Article

Silencing of Hypoxia-Inducible Factor-1β Induces Anti-Tumor Effects in Hepatoma Cell Lines under Tumor Hypoxia

Sung Hoon Choi ,

Contributed equally to this work with: Sung Hoon Choi, Ae Ri Chung

Affiliation Brain Korea 21 plus project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
⨯
Ae Ri Chung ,

Contributed equally to this work with: Sung Hoon Choi, Ae Ri Chung

Affiliation Brain Korea 21 plus project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
⨯
Wonseok Kang,

Affiliations Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Yonsei Liver Cancer Special Clinic, Yonsei University Health System, Seoul, Korea, Liver Cirrhosis Clinical Research Center, Yonsei University Health System, Seoul, Korea
⨯
Jun Yong Park,

Affiliations Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Yonsei Liver Cancer Special Clinic, Yonsei University Health System, Seoul, Korea, Liver Cirrhosis Clinical Research Center, Yonsei University Health System, Seoul, Korea
⨯
Mi Sol Lee,

Affiliation Department of Premed, Yonsei University College of Medicine, Seoul, Korea
⨯
Shin Won Hwang,

Affiliation Department of Premed, Yonsei University College of Medicine, Seoul, Korea
⨯
Do Young Kim,

Affiliations Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Yonsei Liver Cancer Special Clinic, Yonsei University Health System, Seoul, Korea, Liver Cirrhosis Clinical Research Center, Yonsei University Health System, Seoul, Korea
⨯
Seung Up Kim,

Affiliations Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Yonsei Liver Cancer Special Clinic, Yonsei University Health System, Seoul, Korea, Liver Cirrhosis Clinical Research Center, Yonsei University Health System, Seoul, Korea
⨯
Sang Hoon Ahn,

Affiliations Brain Korea 21 plus project for Medical Science, Yonsei University College of Medicine, Seoul, Korea, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Yonsei Liver Cancer Special Clinic, Yonsei University Health System, Seoul, Korea, Liver Cirrhosis Clinical Research Center, Yonsei University Health System, Seoul, Korea
⨯
Seungtaek Kim,

Affiliations Brain Korea 21 plus project for Medical Science, Yonsei University College of Medicine, Seoul, Korea, Liver Cirrhosis Clinical Research Center, Yonsei University Health System, Seoul, Korea
⨯
Kwang-Hyub Han

* E-mail: gihankhys@yuhs.ac

Affiliations Brain Korea 21 plus project for Medical Science, Yonsei University College of Medicine, Seoul, Korea, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Yonsei Liver Cancer Special Clinic, Yonsei University Health System, Seoul, Korea, Liver Cirrhosis Clinical Research Center, Yonsei University Health System, Seoul, Korea
⨯

Silencing of Hypoxia-Inducible Factor-1β Induces Anti-Tumor Effects in Hepatoma Cell Lines under Tumor Hypoxia

Sung Hoon Choi,
Ae Ri Chung,
Wonseok Kang,
Jun Yong Park,
Mi Sol Lee,
Shin Won Hwang,
Do Young Kim,
Seung Up Kim,
Sang Hoon Ahn,
Seungtaek Kim

Published: July 28, 2014
https://doi.org/10.1371/journal.pone.0103304

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hypoxia
Is the Subject Area "Hypoxia" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Hepatocellular carcinoma
Is the Subject Area "Hepatocellular carcinoma" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Epidermal growth factor
Is the Subject Area "Epidermal growth factor" applicable to this article?

Thanks for your feedback.
Fibroblast growth factor
Is the Subject Area "Fibroblast growth factor" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.