Carbamoylating Activity Associated with the Activation of the Antitumor Agent Laromustine Inhibits Angiogenesis by Inducing ASK1-Dependent Endothelial Cell Death

• Weidong Ji ,

  Contributed equally to this work with: Weidong Ji, Mei Yang

  Affiliation No.1 Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

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• Mei Yang ,

  Contributed equally to this work with: Weidong Ji, Mei Yang

  Affiliation Breast Disease Center, Guangdong Women and Children Hospital of Guangzhou Medical University, Guangzhou, P.R. China

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• Alexandra Praggastis,

  Affiliation Department of Chemistry, Colby College, Waterville, Maine, United States of America

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• Yonghao Li,

  Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China

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• Huanjiao Jenny Zhou,

  Affiliation Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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• Yun He,

  Affiliation No.1 Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

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• Roxanne Ghazvinian,

  Affiliation Department of Chemistry, Colby College, Waterville, Maine, United States of America

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• Dylan J. Cincotta,

  Affiliation Department of Chemistry, Colby College, Waterville, Maine, United States of America

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• Kevin P. Rice ,

  * E-mail: wang.min@yale.edu (WM); kevin.rice@colby.edu (KPR)

  Affiliation Department of Chemistry, Colby College, Waterville, Maine, United States of America

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• Wang Min

  * E-mail: wang.min@yale.edu (WM); kevin.rice@colby.edu (KPR)

  Affiliations No.1 Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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