Elevated Heart Rate Triggers Action Potential Alternans and Sudden Death. Translational Study of a Homozygous KCNH2 Mutation

• Ulrich Schweigmann ,

  Contributed equally to this work with: Ulrich Schweigmann, Peter Biliczki, Rafael J. Ramirez

  Affiliation Pediatric Cardiology, Innsbruck Medical University, Innsbruck, Austria

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• Peter Biliczki ,

  Contributed equally to this work with: Ulrich Schweigmann, Peter Biliczki, Rafael J. Ramirez

  Affiliations Division of Clinical Electrophysiology, Goethe University, Frankfurt, Germany, Div. of Cardiology, Deutsche Klinik für Diagnostik, Wiesbaden, Germany

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• Rafael J. Ramirez ,

  Contributed equally to this work with: Ulrich Schweigmann, Peter Biliczki, Rafael J. Ramirez

  Affiliation Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, United States of America

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• Christoph Marschall,

  Affiliation Laboratory for Human Genetics, Martinsried, Germany

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• Ina Takac,

  Affiliation Institute of Cardiovascular Physiology, Goethe University, Frankfurt, Germany

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• Ralf P. Brandes,

  Affiliation Institute of Cardiovascular Physiology, Goethe University, Frankfurt, Germany

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• Dieter Kotzot,

  Affiliation Section for Human Genetics, Innsbruck Medical University, Innsbruck, Austria

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• Zenawit Girmatsion,

  Affiliation Division of Clinical Electrophysiology, Goethe University, Frankfurt, Germany

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• Stefan H. Hohnloser,

  Affiliation Division of Clinical Electrophysiology, Goethe University, Frankfurt, Germany

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• Joachim R. Ehrlich

  * E-mail: joachimehrlich@t-online.de

  Affiliations Division of Clinical Electrophysiology, Goethe University, Frankfurt, Germany, Div. of Cardiology, Deutsche Klinik für Diagnostik, Wiesbaden, Germany

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