Inflammatory Stress Increases Hepatic CD36 Translational Efficiency via Activation of the mTOR Signalling Pathway

Chuan Wang; Lin Hu; Lei Zhao; Ping Yang; John F. Moorhead; Zac Varghese; Yaxi Chen; Xiong Z. Ruan

doi:10.1371/journal.pone.0103071

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Peer-reviewed

Research Article

Inflammatory Stress Increases Hepatic CD36 Translational Efficiency via Activation of the mTOR Signalling Pathway

Chuan Wang,

Affiliation Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Lin Hu,

Affiliation Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Lei Zhao,

Affiliation Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Ping Yang,

Affiliation Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
John F. Moorhead,

Affiliation John Moorhead Research Laboratory, Centre for Nephrology, University College London (UCL) Medical School, Royal Free Campus, University College London, United Kingdom
⨯
Zac Varghese,

Affiliation John Moorhead Research Laboratory, Centre for Nephrology, University College London (UCL) Medical School, Royal Free Campus, University College London, United Kingdom
⨯
Yaxi Chen ,

* E-mail: chenyaxi@cqmu.edu.cn (YC); x.ruan@ucl.ac.uk (XZR)

Affiliation Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Xiong Z. Ruan

* E-mail: chenyaxi@cqmu.edu.cn (YC); x.ruan@ucl.ac.uk (XZR)

Affiliation Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯

Inflammatory Stress Increases Hepatic CD36 Translational Efficiency via Activation of the mTOR Signalling Pathway

Chuan Wang,
Lin Hu,
Lei Zhao,
Ping Yang,
John F. Moorhead,
Zac Varghese,
Yaxi Chen,
Xiong Z. Ruan

Published: July 21, 2014
https://doi.org/10.1371/journal.pone.0103071

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Inflammation
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Protein translation
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Stress signaling cascade
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Casein
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Messenger RNA
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Inflammatory diseases
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Lipids
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Phosphorylation
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