FTY720 Induces Apoptosis of M2 Subtype Acute Myeloid Leukemia Cells by Targeting Sphingolipid Metabolism and Increasing Endogenous Ceramide Levels

• Limin Chen ,

  Contributed equally to this work with: Limin Chen, Liu-Fei Luo, Junyan Lu

  Affiliations State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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• Liu-Fei Luo ,

  Contributed equally to this work with: Limin Chen, Liu-Fei Luo, Junyan Lu

  Affiliation State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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• Junyan Lu ,

  Contributed equally to this work with: Limin Chen, Liu-Fei Luo, Junyan Lu

  Affiliation Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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• Lianchun Li,

  Affiliation Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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• Yuan-Fang Liu,

  Affiliation State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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• Jiang Wang,

  Affiliation Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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• Hong Liu,

  Affiliation Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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• Heng Song,

  Affiliation Department of Chemistry, East China University of Science and Technology, Shanghai, China

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• Hualiang Jiang,

  Affiliation Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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• Sai-Juan Chen,

  Affiliation State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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• Cheng Luo ,

  * E-mail: cluo@simm.ac.cn (CL); kli@epigenetic.us (KKL)

  ¶These authors are co-senior authors on this work.

  Affiliation Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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• Keqin Kathy Li

  * E-mail: cluo@simm.ac.cn (CL); kli@epigenetic.us (KKL)

  ¶These authors are co-senior authors on this work.

  Affiliation State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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