Inhibition of the MDM2 E3 Ligase Induces Apoptosis and Autophagy in Wild-Type and Mutant p53 Models of Multiple Myeloma, and Acts Synergistically with ABT-737

Dongmin Gu; Shuhong Wang; Isere Kuiatse; Hua Wang; Jin He; Yun Dai; Richard J. Jones; Chad C. Bjorklund; Jing Yang; Steven Grant; Robert Z. Orlowski

doi:10.1371/journal.pone.0103015

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Peer-reviewed

Research Article

Inhibition of the MDM2 E3 Ligase Induces Apoptosis and Autophagy in Wild-Type and Mutant p53 Models of Multiple Myeloma, and Acts Synergistically with ABT-737

Dongmin Gu ,

Contributed equally to this work with: Dongmin Gu, Shuhong Wang

Affiliation Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Shuhong Wang ,

Contributed equally to this work with: Dongmin Gu, Shuhong Wang

Affiliation Department of Hematology, Chinese PLA General Hospital, Beijing, China
⨯
Isere Kuiatse,

Affiliation Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Hua Wang,

Affiliation Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Jin He,

Affiliation Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Yun Dai,

Affiliation Department of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Richard J. Jones,

Affiliation Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Chad C. Bjorklund,

Affiliation Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Jing Yang,

Affiliation Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Steven Grant,

Affiliation Department of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Robert Z. Orlowski

* E-mail: rorlowsk@mdanderson.org

Affiliations Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯

Inhibition of the MDM2 E3 Ligase Induces Apoptosis and Autophagy in Wild-Type and Mutant p53 Models of Multiple Myeloma, and Acts Synergistically with ABT-737

Dongmin Gu,
Shuhong Wang,
Isere Kuiatse,
Hua Wang,
Jin He,
Yun Dai,
Richard J. Jones,
Chad C. Bjorklund,
Jing Yang,
Steven Grant

Published: September 2, 2014
https://doi.org/10.1371/journal.pone.0103015

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Apoptosis
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Multiple myeloma
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Myeloma
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