Widespread Disruption of Functional Brain Organization in Early-Onset Alzheimer’s Disease

Sofie M. Adriaanse; Maja A. A. Binnewijzend; Rik Ossenkoppele; Betty M. Tijms; Wiesje M. van der Flier; Teddy Koene; Lieke L. Smits; Alle Meije Wink; Philip Scheltens; Bart N. M. van Berckel; Frederik Barkhof

doi:10.1371/journal.pone.0102995

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Open Access

Peer-reviewed

Research Article

Widespread Disruption of Functional Brain Organization in Early-Onset Alzheimer’s Disease

Sofie M. Adriaanse ,

* E-mail: s.adriaanse@vumc.nl

Affiliations Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
⨯
Maja A. A. Binnewijzend,

Affiliations Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Department of Neurology/Alzheimercenter Amsterdam, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
⨯
Rik Ossenkoppele,

Affiliations Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
⨯
Betty M. Tijms,

Affiliations Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Department of Neurology/Alzheimercenter Amsterdam, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
⨯
Wiesje M. van der Flier,

Affiliations Department of Neurology/Alzheimercenter Amsterdam, VU University Medical Center, Amsterdam, The Netherlands, Department of Epidemiology and biostatistics, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
⨯
Teddy Koene,

Affiliation Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands
⨯
Lieke L. Smits,

Affiliations Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
⨯
Alle Meije Wink,

Affiliations Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
⨯
Philip Scheltens,

Affiliations Department of Neurology/Alzheimercenter Amsterdam, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
⨯
Bart N. M. van Berckel,

Affiliations Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
⨯
Frederik Barkhof

Affiliations Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
⨯

Widespread Disruption of Functional Brain Organization in Early-Onset Alzheimer’s Disease

Sofie M. Adriaanse,
Maja A. A. Binnewijzend,
Rik Ossenkoppele,
Betty M. Tijms,
Wiesje M. van der Flier,
Teddy Koene,
Lieke L. Smits,
Alle Meije Wink,
Philip Scheltens,
Bart N. M. van Berckel

Published: July 31, 2014
https://doi.org/10.1371/journal.pone.0102995

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