TNF-α Mediated Increase of HIF-1α Inhibits VASP Expression, Which Reduces Alveolar-Capillary Barrier Function during Acute Lung Injury (ALI)

Mengjie Tang; Yihao Tian; Doulin Li; Jiawei Lv; Qun Li; Changchun Kuang; Pengchao Hu; Ying Wang; Jing Wang; Ke Su; Lei Wei

doi:10.1371/journal.pone.0102967

Loading metrics

Open Access

Peer-reviewed

Research Article

TNF-α Mediated Increase of HIF-1α Inhibits VASP Expression, Which Reduces Alveolar-Capillary Barrier Function during Acute Lung Injury (ALI)

Mengjie Tang ,

Contributed equally to this work with: Mengjie Tang, Yihao Tian

Affiliations Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, PR China, Hunan Provincial Tumor Hospital, the Affiliated Tumor Hospital of Xiangya Medical School of Central South University, Changsha, Hunan, PR China
⨯
Yihao Tian ,

Contributed equally to this work with: Mengjie Tang, Yihao Tian

Affiliation Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, PR China
⨯
Doulin Li,

Affiliation Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, PR China
⨯
Jiawei Lv,

Affiliation Zhongnan Hospital of Wuhan University, the Second College of Clinical Medicine of Wuhan University, Wuhan, Hubei, PR China
⨯
Qun Li,

Affiliation Renmin Hospital of Wuhan University, the First College of Clinical Medicine of Wuhan University, Wuhan, Hubei, PR China
⨯
Changchun Kuang,

Affiliation Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, PR China
⨯
Pengchao Hu,

Affiliation Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, PR China
⨯
Ying Wang,

Affiliation Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, PR China
⨯
Jing Wang,

Affiliation Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, PR China
⨯
Ke Su,

Affiliation Renmin Hospital of Wuhan University, Division of Nephrology, Wuhan, Hubei, PR China
⨯
Lei Wei

* E-mail: leiweifr@hotmail.com

Affiliation Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, PR China
⨯

TNF-α Mediated Increase of HIF-1α Inhibits VASP Expression, Which Reduces Alveolar-Capillary Barrier Function during Acute Lung Injury (ALI)

Mengjie Tang,
Yihao Tian,
Doulin Li,
Jiawei Lv,
Qun Li,
Changchun Kuang,
Pengchao Hu,
Ying Wang,
Jing Wang,
Ke Su

Published: July 22, 2014
https://doi.org/10.1371/journal.pone.0102967

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Permeability
Is the Subject Area "Permeability" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Vascular permeability
Is the Subject Area "Vascular permeability" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.
Body weight
Is the Subject Area "Body weight" applicable to this article?

Thanks for your feedback.