Antitumor Effects of a Sirtuin Inhibitor, Tenovin-6, against Gastric Cancer Cells via Death Receptor 5 Up-Regulation

Sachiko Hirai; Shinji Endo; Rie Saito; Mitsuaki Hirose; Takunori Ueno; Hideo Suzuki; Kenji Yamato; Masato Abei; Ichinosuke Hyodo

doi:10.1371/journal.pone.0102831

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Peer-reviewed

Research Article

Antitumor Effects of a Sirtuin Inhibitor, Tenovin-6, against Gastric Cancer Cells via Death Receptor 5 Up-Regulation

Sachiko Hirai,

Affiliation Department of Gastroenterology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
⨯
Shinji Endo ,

* E-mail: shinj.endo@md.tsukuba.ac.jp

Affiliation Department of Gastroenterology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
⨯
Rie Saito,

Affiliation Department of Gastroenterology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
⨯
Mitsuaki Hirose,

Affiliation Department of Gastroenterology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
⨯
Takunori Ueno,

Affiliation Department of Gastroenterology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
⨯
Hideo Suzuki,

Affiliation Department of Gastroenterology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
⨯
Kenji Yamato,

Affiliation Department of Gastroenterology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
⨯
Masato Abei,

Affiliation Department of Gastroenterology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
⨯
Ichinosuke Hyodo

Affiliation Department of Gastroenterology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
⨯

Antitumor Effects of a Sirtuin Inhibitor, Tenovin-6, against Gastric Cancer Cells via Death Receptor 5 Up-Regulation

Sachiko Hirai,
Shinji Endo,
Rie Saito,
Mitsuaki Hirose,
Takunori Ueno,
Hideo Suzuki,
Kenji Yamato,
Masato Abei,
Ichinosuke Hyodo

Published: July 17, 2014
https://doi.org/10.1371/journal.pone.0102831

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