Aurora Kinases as Druggable Targets in Pediatric Leukemia: Heterogeneity in Target Modulation Activities and Cytotoxicity by Diverse Novel Therapeutic Agents

Open Access

Peer-reviewed

Research Article

Aarthi Jayanthan,

Affiliation Pediatric Oncology Experimental Therapeutics Investigators Consortium (POETIC) Laboratory for Pre-Clinical and Drug Discovery Studies, University of Calgary, Calgary, Alberta, Canada
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Yibing Ruan,

Affiliation Pediatric Oncology Experimental Therapeutics Investigators Consortium (POETIC) Laboratory for Pre-Clinical and Drug Discovery Studies, University of Calgary, Calgary, Alberta, Canada
⨯
Tony H. Truong,

Affiliation Division of Pediatric Oncology, Alberta Children's Hospital, Calgary, Alberta, Canada
⨯
Aru Narendran

* E-mail: a.narendran@ucalgary.ca

Affiliations Pediatric Oncology Experimental Therapeutics Investigators Consortium (POETIC) Laboratory for Pre-Clinical and Drug Discovery Studies, University of Calgary, Calgary, Alberta, Canada, Division of Pediatric Oncology, Alberta Children's Hospital, Calgary, Alberta, Canada
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Protein kinases
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Phosphorylation
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Small interfering RNA
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Aurora
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Leukemia
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Leukemia cells
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Apoptosis
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Pediatrics
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