Reversion and T Cell Escape Mutations Compensate the Fitness Loss of a CD8+ T Cell Escape Mutant in Their Cognate Transmitted/Founder Virus

Hongshuo Song; Bhavna Hora; Tanmoy Bhattacharya; Nilu Goonetilleke; Michael K. P. Liu; Kevin Wiehe; Hui Li; Shilpa S. Iyer; Andrew J. McMichael; Alan S. Perelson; Feng Gao

doi:10.1371/journal.pone.0102734

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Open Access

Peer-reviewed

Research Article

Reversion and T Cell Escape Mutations Compensate the Fitness Loss of a CD8⁺ T Cell Escape Mutant in Their Cognate Transmitted/Founder Virus

Hongshuo Song,

Affiliation Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Bhavna Hora,

Affiliation Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Tanmoy Bhattacharya,

Affiliations Theoretical Division, Los Alamos National laboratory, Los Alamos, New Mexico, United States of America, Santa Fe Institute, Santa Fe, New Mexico, United States of America
⨯
Nilu Goonetilleke,

Affiliation Weatherall Institute of molecular Medicine, University of Oxford, Oxford, England, United Kingdom
⨯
Michael K. P. Liu,

Affiliation Weatherall Institute of molecular Medicine, University of Oxford, Oxford, England, United Kingdom
⨯
Kevin Wiehe,

Affiliation Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Hui Li,

Affiliation Departments of Medicine and Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Shilpa S. Iyer,

Affiliation Departments of Medicine and Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Andrew J. McMichael,

Affiliation Weatherall Institute of molecular Medicine, University of Oxford, Oxford, England, United Kingdom
⨯
Alan S. Perelson,

Affiliation Theoretical Division, Los Alamos National laboratory, Los Alamos, New Mexico, United States of America
⨯
Feng Gao

* E-mail: fgao@duke.edu

Affiliation Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America
⨯

Reversion and T Cell Escape Mutations Compensate the Fitness Loss of a CD8⁺ T Cell Escape Mutant in Their Cognate Transmitted/Founder Virus

Hongshuo Song,
Bhavna Hora,
Tanmoy Bhattacharya,
Nilu Goonetilleke,
Michael K. P. Liu,
Kevin Wiehe,
Hui Li,
Shilpa S. Iyer,
Andrew J. McMichael,
Alan S. Perelson

Published: July 16, 2014
https://doi.org/10.1371/journal.pone.0102734

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