5-Lipoxygenase Activating Protein (FLAP) Dependent Leukotriene Biosynthesis Inhibition (MK591) Attenuates Lipid A Endotoxin-Induced Inflammation

Wen-Feng Fang; Ivor S. Douglas; Chin-Chou Wang; Hsu-Ching Kao; Ya-Ting Chang; Chia-Cheng Tseng; Kuo-Tung Huang; Huang-Chih Chang; Meng-Chih Lin

doi:10.1371/journal.pone.0102622

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Peer-reviewed

Research Article

5-Lipoxygenase Activating Protein (FLAP) Dependent Leukotriene Biosynthesis Inhibition (MK591) Attenuates Lipid A Endotoxin-Induced Inflammation

Wen-Feng Fang ,

* E-mail: wenfengfang@yahoo.com.tw (WFF); idouglas@dhha.org (ISD); mengchih@adm.cgmh.org.tw (MCL)

Affiliations Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi Campus, Chiayi, Taiwan
⨯
Ivor S. Douglas ,

* E-mail: wenfengfang@yahoo.com.tw (WFF); idouglas@dhha.org (ISD); mengchih@adm.cgmh.org.tw (MCL)

Affiliation Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Denver and Denver Health Medical Center, Denver, Colorado, United States of America
⨯
Chin-Chou Wang,

Affiliations Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi Campus, Chiayi, Taiwan
⨯
Hsu-Ching Kao,

Affiliation Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
⨯
Ya-Ting Chang,

Affiliation Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
⨯
Chia-Cheng Tseng,

Affiliation Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
⨯
Kuo-Tung Huang,

Affiliation Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
⨯
Huang-Chih Chang,

Affiliation Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
⨯
Meng-Chih Lin

* E-mail: wenfengfang@yahoo.com.tw (WFF); idouglas@dhha.org (ISD); mengchih@adm.cgmh.org.tw (MCL)

Affiliations Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi Campus, Chiayi, Taiwan
⨯

5-Lipoxygenase Activating Protein (FLAP) Dependent Leukotriene Biosynthesis Inhibition (MK591) Attenuates Lipid A Endotoxin-Induced Inflammation

Wen-Feng Fang,
Ivor S. Douglas,
Chin-Chou Wang,
Hsu-Ching Kao,
Ya-Ting Chang,
Chia-Cheng Tseng,
Kuo-Tung Huang,
Huang-Chih Chang,
Meng-Chih Lin

Published: July 15, 2014
https://doi.org/10.1371/journal.pone.0102622

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Toll-like receptors
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Biosynthesis
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Immunoblotting
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