Host Cytokine Responses Induced after Overnight Stimulation with Novel M. tuberculosis Infection Phase-Dependent Antigens Show Promise as Diagnostic Candidates for TB Disease

Paulin N. Essone; Novel N. Chegou; Andre G. Loxton; Kim Stanley; Magdalena Kriel; Gian van der Spuy; Kees L. Franken; Tom H. Ottenhoff; Gerhard Walzl

doi:10.1371/journal.pone.0102584

Loading metrics

Open Access

Peer-reviewed

Research Article

Host Cytokine Responses Induced after Overnight Stimulation with Novel M. tuberculosis Infection Phase-Dependent Antigens Show Promise as Diagnostic Candidates for TB Disease

Paulin N. Essone,

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Novel N. Chegou,

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Andre G. Loxton,

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Kim Stanley,

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Magdalena Kriel,

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Gian van der Spuy,

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Kees L. Franken,

Affiliation Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
⨯
Tom H. Ottenhoff,

Affiliation Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
⨯
Gerhard Walzl

* E-mail: gwalzl@sun.ac.za

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯

Host Cytokine Responses Induced after Overnight Stimulation with Novel M. tuberculosis Infection Phase-Dependent Antigens Show Promise as Diagnostic Candidates for TB Disease

Paulin N. Essone,
Novel N. Chegou,
Andre G. Loxton,
Kim Stanley,
Magdalena Kriel,
Gian van der Spuy,
Kees L. Franken,
Tom H. Ottenhoff,
Gerhard Walzl

Published: July 15, 2014
https://doi.org/10.1371/journal.pone.0102584

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Tuberculosis
Is the Subject Area "Tuberculosis" applicable to this article?

Thanks for your feedback.
Tuberculosis diagnosis and management
Is the Subject Area "Tuberculosis diagnosis and management" applicable to this article?

Thanks for your feedback.
Diagnostic medicine
Is the Subject Area "Diagnostic medicine" applicable to this article?

Thanks for your feedback.
Blood
Is the Subject Area "Blood" applicable to this article?

Thanks for your feedback.
C-reactive proteins
Is the Subject Area "C-reactive proteins" applicable to this article?

Thanks for your feedback.
Sputum
Is the Subject Area "Sputum" applicable to this article?

Thanks for your feedback.
Mycobacterium tuberculosis
Is the Subject Area "Mycobacterium tuberculosis" applicable to this article?

Thanks for your feedback.
Pilot studies
Is the Subject Area "Pilot studies" applicable to this article?

Thanks for your feedback.