Crosslinking Constraints and Computational Models as Complementary Tools in Modeling the Extracellular Domain of the Glycine Receptor

Open Access

Peer-reviewed

Research Article

Zhenyu Liu,

Affiliation Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Agnieszka Szarecka,

Affiliations Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America, Department of Cell and Molecular Biology, Grand Valley State University, Allendale, Michigan, United States of America
⨯
Michael Yonkunas,

Affiliation Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
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Kirill Speranskiy,

Affiliation Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
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Maria Kurnikova,

Affiliation Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
⨯
Michael Cascio

* E-mail: casciom@duq.edu

Affiliations Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania, United States of America
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Cross-linking
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Protein structure
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Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
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Lysine
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Biochemical simulations
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Crystal structure
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Nicotinic acetylcholine receptors
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Ligand-gated ion channels
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