Lactate and the Lactate-to-Pyruvate Molar Ratio Cannot Be Used as Independent Biomarkers for Monitoring Brain Energetic Metabolism: A Microdialysis Study in Patients with Traumatic Brain Injuries

Juan Sahuquillo; Maria-Angels Merino; Angela Sánchez-Guerrero; Fuat Arikan; Marian Vidal-Jorge; Tamara Martínez-Valverde; Anna Rey; Marilyn Riveiro; Maria-Antonia Poca

doi:10.1371/journal.pone.0102540

Loading metrics

Open Access

Peer-reviewed

Research Article

Lactate and the Lactate-to-Pyruvate Molar Ratio Cannot Be Used as Independent Biomarkers for Monitoring Brain Energetic Metabolism: A Microdialysis Study in Patients with Traumatic Brain Injuries

Juan Sahuquillo ,

* E-mail: sahuquillo@neurotrauma.net

Affiliations Department of Neurosurgery, Vall d’Hebron University Hospital, Universidad Autonoma de Barcelona, Barcelona, Spain, Neurotraumatology and Neurosurgery Research Unit (UNINN), Vall d’Hebron University Hospital, Universidad Autonoma de Barcelona, Barcelona, Spain
⨯
Maria-Angels Merino,

Affiliation Neurotraumatology and Neurosurgery Research Unit (UNINN), Vall d’Hebron University Hospital, Universidad Autonoma de Barcelona, Barcelona, Spain
⨯
Angela Sánchez-Guerrero,

Affiliation Neurotraumatology and Neurosurgery Research Unit (UNINN), Vall d’Hebron University Hospital, Universidad Autonoma de Barcelona, Barcelona, Spain
⨯
Fuat Arikan,

Affiliations Department of Neurosurgery, Vall d’Hebron University Hospital, Universidad Autonoma de Barcelona, Barcelona, Spain, Neurotraumatology and Neurosurgery Research Unit (UNINN), Vall d’Hebron University Hospital, Universidad Autonoma de Barcelona, Barcelona, Spain
⨯
Marian Vidal-Jorge,

Affiliation Neurotraumatology and Neurosurgery Research Unit (UNINN), Vall d’Hebron University Hospital, Universidad Autonoma de Barcelona, Barcelona, Spain
⨯
Tamara Martínez-Valverde,

Affiliation Neurotraumatology and Neurosurgery Research Unit (UNINN), Vall d’Hebron University Hospital, Universidad Autonoma de Barcelona, Barcelona, Spain
⨯
Anna Rey,

Affiliation Neurotraumatology Intensive Care Unit, Vall d’Hebron University Hospital, Universidad Autonoma de Barcelona, Barcelona, Spain
⨯
Marilyn Riveiro,

Affiliations Neurotraumatology and Neurosurgery Research Unit (UNINN), Vall d’Hebron University Hospital, Universidad Autonoma de Barcelona, Barcelona, Spain, Neurotraumatology Intensive Care Unit, Vall d’Hebron University Hospital, Universidad Autonoma de Barcelona, Barcelona, Spain
⨯
Maria-Antonia Poca

Affiliations Department of Neurosurgery, Vall d’Hebron University Hospital, Universidad Autonoma de Barcelona, Barcelona, Spain, Neurotraumatology and Neurosurgery Research Unit (UNINN), Vall d’Hebron University Hospital, Universidad Autonoma de Barcelona, Barcelona, Spain
⨯

Lactate and the Lactate-to-Pyruvate Molar Ratio Cannot Be Used as Independent Biomarkers for Monitoring Brain Energetic Metabolism: A Microdialysis Study in Patients with Traumatic Brain Injuries

Juan Sahuquillo,
Maria-Angels Merino,
Angela Sánchez-Guerrero,
Fuat Arikan,
Marian Vidal-Jorge,
Tamara Martínez-Valverde,
Anna Rey,
Marilyn Riveiro,
Maria-Antonia Poca

Published: July 15, 2014
https://doi.org/10.1371/journal.pone.0102540

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Pyruvate
Is the Subject Area "Pyruvate" applicable to this article?

Thanks for your feedback.
Traumatic brain injury
Is the Subject Area "Traumatic brain injury" applicable to this article?

Thanks for your feedback.
Glucose metabolism
Is the Subject Area "Glucose metabolism" applicable to this article?

Thanks for your feedback.
Glucose
Is the Subject Area "Glucose" applicable to this article?

Thanks for your feedback.
Medical hypoxia
Is the Subject Area "Medical hypoxia" applicable to this article?

Thanks for your feedback.
Energy metabolism
Is the Subject Area "Energy metabolism" applicable to this article?

Thanks for your feedback.
Oxygen
Is the Subject Area "Oxygen" applicable to this article?

Thanks for your feedback.
Brain damage
Is the Subject Area "Brain damage" applicable to this article?

Thanks for your feedback.