Transgene Regulation Using the Tetracycline-Inducible TetR-KRAB System after AAV-Mediated Gene Transfer in Rodents and Nonhuman Primates

Caroline Le Guiner; Knut Stieger; Alice Toromanoff; Mickaël Guilbaud; Alexandra Mendes-Madeira; Marie Devaux; Lydie Guigand; Yan Cherel; Philippe Moullier; Fabienne Rolling; Oumeya Adjali

doi:10.1371/journal.pone.0102538

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Peer-reviewed

Research Article

Transgene Regulation Using the Tetracycline-Inducible TetR-KRAB System after AAV-Mediated Gene Transfer in Rodents and Nonhuman Primates

Caroline Le Guiner ,

Contributed equally to this work with: Caroline Le Guiner, Knut Stieger, Alice Toromanoff

Affiliation INSERM UMR 1089, Atlantic Gene Therapies, Nantes University Hospital, Nantes, France
⨯
Knut Stieger ,

Contributed equally to this work with: Caroline Le Guiner, Knut Stieger, Alice Toromanoff

Affiliations INSERM UMR 1089, Atlantic Gene Therapies, Nantes University Hospital, Nantes, France, Department of Ophthalmology, Faculty of Medicine, Justus-Liebig-University Giessen, Giessen, Germany
⨯
Alice Toromanoff ,

Contributed equally to this work with: Caroline Le Guiner, Knut Stieger, Alice Toromanoff

Affiliation INSERM UMR 1089, Atlantic Gene Therapies, Nantes University Hospital, Nantes, France
⨯
Mickaël Guilbaud,

Affiliation INSERM UMR 1089, Atlantic Gene Therapies, Nantes University Hospital, Nantes, France
⨯
Alexandra Mendes-Madeira,

Affiliation INSERM UMR 1089, Atlantic Gene Therapies, Nantes University Hospital, Nantes, France
⨯
Marie Devaux,

Affiliation INSERM UMR 1089, Atlantic Gene Therapies, Nantes University Hospital, Nantes, France
⨯
Lydie Guigand,

Affiliation INRA UMR 703 and Atlantic Gene Therapies, ONIRIS, Nantes, France
⨯
Yan Cherel,

Affiliation INRA UMR 703 and Atlantic Gene Therapies, ONIRIS, Nantes, France
⨯
Philippe Moullier,

Affiliations INSERM UMR 1089, Atlantic Gene Therapies, Nantes University Hospital, Nantes, France, Department of Molecular Genetics and Microbiology department, University of Florida, Gainesville, Florida, United States of America
⨯
Fabienne Rolling ,

* E-mail: fabienne.rolling@univ-nantes.fr (FR); oumeya.adjali@univ-nantes.fr (OA)

Affiliation INSERM UMR 1089, Atlantic Gene Therapies, Nantes University Hospital, Nantes, France
⨯
Oumeya Adjali

* E-mail: fabienne.rolling@univ-nantes.fr (FR); oumeya.adjali@univ-nantes.fr (OA)

Affiliation INSERM UMR 1089, Atlantic Gene Therapies, Nantes University Hospital, Nantes, France
⨯

Transgene Regulation Using the Tetracycline-Inducible TetR-KRAB System after AAV-Mediated Gene Transfer in Rodents and Nonhuman Primates

Caroline Le Guiner,
Knut Stieger,
Alice Toromanoff,
Mickaël Guilbaud,
Alexandra Mendes-Madeira,
Marie Devaux,
Lydie Guigand,
Yan Cherel,
Philippe Moullier,
Fabienne Rolling

Published: September 23, 2014
https://doi.org/10.1371/journal.pone.0102538

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