Combined Linkage and Association Studies Show that HLA Class II Variants Control Levels of Antibodies against Epstein-Barr Virus Antigens

• Vincent Pedergnana ,

  Contributed equally to this work with: Vincent Pedergnana, Laurène Syx

  Affiliations Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, Paris, France, University Paris Descartes, Sorbonne Paris Cité, Imagine Institute, Paris, France

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• Laurène Syx ,

  Contributed equally to this work with: Vincent Pedergnana, Laurène Syx

  Affiliations Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, Paris, France, University Paris Descartes, Sorbonne Paris Cité, Imagine Institute, Paris, France

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• Aurélie Cobat,

  Affiliations Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, Paris, France, University Paris Descartes, Sorbonne Paris Cité, Imagine Institute, Paris, France

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• Julien Guergnon,

  Affiliation Laboratory of Immunity and Infection, Institut National de la Santé et de la Recherche Médicale UMR-S 945, Université Pierre et Marie Curie Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France

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• Pauline Brice,

  Affiliation Service d’Onco-Hématologie, Hôpital Saint-Louis, Paris, France

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• Christophe Fermé,

  Affiliation Department of Medicine, Hôpital Gustave Roussy, Villejuif, France

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• Patrice Carde,

  Affiliation Department of Medicine, Hôpital Gustave Roussy, Villejuif, France

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• Olivier Hermine,

  Affiliation Service d’Hématologie adultes, Hôpital Necker, Assistance Publique-Hôpitaux de Paris, Paris, France

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• Catherine Le- Pendeven,

  Affiliation Laboratoire de Virologie, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France

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• Corinne Amiel,

  Affiliation Laboratoire de Virologie, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France

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• Yassine Taoufik,

  Affiliation Assistance Publique-Hôpitaux de Paris, CHU Bicetre, Service d’Hématologie et Immunologie Biologiques, Le Kremlin-Bicetre, France, and Université Paris Sud, Faculte de Médecine, Le Kremlin-Bicetre, France, and Institut National de la Santé et de la Recherche Médicale U1012, Le Kremlin-Bicetre, France

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• Alexandre Alcaïs,

  Affiliations Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, Paris, France, University Paris Descartes, Sorbonne Paris Cité, Imagine Institute, Paris, France

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• Ioannis Theodorou,

  Affiliation Laboratory of Immunity and Infection, Institut National de la Santé et de la Recherche Médicale UMR-S 945, Université Pierre et Marie Curie Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France

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• Caroline Besson ,

  * E-mail: caroline.besson@bct.aphp.fr (CB); laurent.abel@inserm.fr (LA)

  ¶These authors also contributed equally to this work.

  Affiliation Assistance Publique-Hôpitaux de Paris, CHU Bicetre, Service d’Hématologie et Immunologie Biologiques, Le Kremlin-Bicetre, France, and Université Paris Sud, Faculte de Médecine, Le Kremlin-Bicetre, France, and Institut National de la Santé et de la Recherche Médicale U1012, Le Kremlin-Bicetre, France

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• Laurent Abel

  * E-mail: caroline.besson@bct.aphp.fr (CB); laurent.abel@inserm.fr (LA)

  ¶These authors also contributed equally to this work.

  Affiliations Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, Paris, France, University Paris Descartes, Sorbonne Paris Cité, Imagine Institute, Paris, France, St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, United States of America

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