Loss of Sirt1 Function Improves Intestinal Anti-Bacterial Defense and Protects from Colitis-Induced Colorectal Cancer

• Giuseppe Lo Sasso,

  Affiliation Laboratory of Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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• Dongryeol Ryu,

  Affiliation Laboratory of Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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• Laurent Mouchiroud,

  Affiliation Laboratory of Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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• Samodha C. Fernando,

  Affiliation Department of Animal Science, University of Nebraska, Lincoln, Nebraska, United States of America

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• Christopher L. Anderson,

  Affiliations Department of Animal Science, University of Nebraska, Lincoln, Nebraska, United States of America, School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America

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• Elena Katsyuba,

  Affiliation Laboratory of Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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• Alessandra Piersigilli,

  Affiliations Laboratory of Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Institute of Animal Pathology, University of Bern, Bern, Switzerland

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• Michael O. Hottiger,

  Affiliation Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland

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• Kristina Schoonjans,

  Affiliation Institute of Bioengineering, School of Life Science, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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• Johan Auwerx

  * E-mail: admin.auwerx@epfl.ch

  Affiliation Laboratory of Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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