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Open Access

Peer-reviewed

Research Article

Quantifying Metabolic Heterogeneity in Head and Neck Tumors in Real Time: 2-DG Uptake Is Highest in Hypoxic Tumor Regions

Erica C. Nakajima,

Affiliations Physician Scientist Training Program, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Howard Hughes Medical Fellow, Howard Hughes Medical Institute, Bethesda, Maryland, United States of America, Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Charles Laymon,

Affiliation Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Matthew Oborski,

Affiliation Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Weizhou Hou,

Affiliation Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Lin Wang,

Affiliation Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Jennifer R. Grandis,

Affiliation Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Robert L. Ferris,

Affiliation Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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James M. Mountz,

Affiliation Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Bennett Van Houten

* E-mail: vanhoutenb@upmc.edu

Affiliation Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

Quantifying Metabolic Heterogeneity in Head and Neck Tumors in Real Time: 2-DG Uptake Is Highest in Hypoxic Tumor Regions

Erica C. Nakajima,
Charles Laymon,
Matthew Oborski,
Weizhou Hou,
Lin Wang,
Jennifer R. Grandis,
Robert L. Ferris,
James M. Mountz,
Bennett Van Houten

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Published: August 15, 2014
https://doi.org/10.1371/journal.pone.0102452

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Hypoxia
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Cancers and neoplasms
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Head and neck cancers
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Cell metabolism
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Glucose metabolism
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Malignant tumors
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Non-small cell lung cancer
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Positron emission tomography
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