P-Glycoprotein Mediated Efflux Limits the Transport of the Novel Anti-Parkinson's Disease Candidate Drug FLZ across the Physiological and PD Pathological In Vitro BBB Models

Qian Liu; Jinfeng Hou; Xiaoguang Chen; Gengtao Liu; Dan Zhang; Hua Sun; Jinlan Zhang

doi:10.1371/journal.pone.0102442

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Open Access

Peer-reviewed

Research Article

P-Glycoprotein Mediated Efflux Limits the Transport of the Novel Anti-Parkinson's Disease Candidate Drug FLZ across the Physiological and PD Pathological In Vitro BBB Models

Qian Liu,

Affiliations State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
⨯
Jinfeng Hou,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Xiaoguang Chen,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Gengtao Liu,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Dan Zhang,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Hua Sun ,

* E-mail: sunhua@imm.ac.cn (HS) (HS); zhjl@imm.ac.cn (JZ) (JZ)

Current address: Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Jinlan Zhang

* E-mail: sunhua@imm.ac.cn (HS) (HS); zhjl@imm.ac.cn (JZ) (JZ)

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯

P-Glycoprotein Mediated Efflux Limits the Transport of the Novel Anti-Parkinson's Disease Candidate Drug FLZ across the Physiological and PD Pathological In Vitro BBB Models

Qian Liu,
Jinfeng Hou,
Xiaoguang Chen,
Gengtao Liu,
Dan Zhang,
Hua Sun,
Jinlan Zhang

Published: July 18, 2014
https://doi.org/10.1371/journal.pone.0102442

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