MUC1 Positive, Kras and Pten Driven Mouse Gynecologic Tumors Replicate Human Tumors and Vary in Survival and Nuclear Grade Based on Anatomical Location

Tejas S. Tirodkar; Raluca A. Budiu; Esther Elishaev; Lixin Zhang; Jyothi T. Mony; Joan Brozick; Robert P. Edwards; Anda M. Vlad

doi:10.1371/journal.pone.0102409

Loading metrics

Open Access

Peer-reviewed

Research Article

MUC1 Positive, Kras and Pten Driven Mouse Gynecologic Tumors Replicate Human Tumors and Vary in Survival and Nuclear Grade Based on Anatomical Location

Tejas S. Tirodkar ,

Contributed equally to this work with: Tejas S. Tirodkar, Raluca A. Budiu

Affiliations Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Magee Women's Research Institute, Pittsburgh, Pennsylvania, United States of America
⨯
Raluca A. Budiu ,

Contributed equally to this work with: Tejas S. Tirodkar, Raluca A. Budiu

Current address: Department of Developmental and Regenerative Biology, Icahn School of Medicine, Mt. Sinai, New York, New York, United States of America

Affiliations Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Magee Women's Research Institute, Pittsburgh, Pennsylvania, United States of America
⨯
Esther Elishaev,

Affiliations Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Pathology, Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Lixin Zhang,

Affiliations Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Magee Women's Research Institute, Pittsburgh, Pennsylvania, United States of America
⨯
Jyothi T. Mony,

Affiliations Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Magee Women's Research Institute, Pittsburgh, Pennsylvania, United States of America
⨯
Joan Brozick,

Affiliation Magee Women's Research Institute, Pittsburgh, Pennsylvania, United States of America
⨯
Robert P. Edwards,

Affiliations Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Magee Women's Research Institute, Pittsburgh, Pennsylvania, United States of America, Magee-Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Anda M. Vlad

* E-mail: vladam@upmc.edu

Affiliations Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Magee Women's Research Institute, Pittsburgh, Pennsylvania, United States of America
⨯

MUC1 Positive, Kras and Pten Driven Mouse Gynecologic Tumors Replicate Human Tumors and Vary in Survival and Nuclear Grade Based on Anatomical Location

Tejas S. Tirodkar,
Raluca A. Budiu,
Esther Elishaev,
Lixin Zhang,
Jyothi T. Mony,
Joan Brozick,
Robert P. Edwards,
Anda M. Vlad

Published: July 31, 2014
https://doi.org/10.1371/journal.pone.0102409

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Uterine cancer
Is the Subject Area "Uterine cancer" applicable to this article?

Thanks for your feedback.
Ovarian cancer
Is the Subject Area "Ovarian cancer" applicable to this article?

Thanks for your feedback.
Gynecologic cancers
Is the Subject Area "Gynecologic cancers" applicable to this article?

Thanks for your feedback.
Gynecological tumors
Is the Subject Area "Gynecological tumors" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Ovaries
Is the Subject Area "Ovaries" applicable to this article?

Thanks for your feedback.
Genetically modified animals
Is the Subject Area "Genetically modified animals" applicable to this article?

Thanks for your feedback.
Histology
Is the Subject Area "Histology" applicable to this article?

Thanks for your feedback.