Adipose Tissue-Derived Mesenchymal Stem Cells in Long-Term Dialysis Patients Display Downregulation of PCAF Expression and Poor Angiogenesis Activation

Shuichiro Yamanaka; Shinya Yokote; Akifumi Yamada; Yuichi Katsuoka; Luna Izuhara; Yohta Shimada; Nobuo Omura; Hirotaka James Okano; Takao Ohki; Takashi Yokoo

doi:10.1371/journal.pone.0102311

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Peer-reviewed

Research Article

Adipose Tissue-Derived Mesenchymal Stem Cells in Long-Term Dialysis Patients Display Downregulation of PCAF Expression and Poor Angiogenesis Activation

Shuichiro Yamanaka,

Affiliations Division of Regenerative Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan, Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
⨯
Shinya Yokote,

Affiliation Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
⨯
Akifumi Yamada,

Affiliation Department of Pediatrics, The Jikei University School of Medicine, Tokyo, Japan
⨯
Yuichi Katsuoka,

Affiliation Division of Regenerative Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
⨯
Luna Izuhara,

Affiliation Division of Regenerative Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
⨯
Yohta Shimada,

Affiliation Department of Gene Therapy, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan
⨯
Nobuo Omura,

Affiliation Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
⨯
Hirotaka James Okano,

Affiliation Division of Regenerative Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
⨯
Takao Ohki,

Affiliation Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
⨯
Takashi Yokoo

* E-mail: tyokoo@jikei.ac.jp

Affiliation Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
⨯

Adipose Tissue-Derived Mesenchymal Stem Cells in Long-Term Dialysis Patients Display Downregulation of PCAF Expression and Poor Angiogenesis Activation

Shuichiro Yamanaka,
Shinya Yokote,
Akifumi Yamada,
Yuichi Katsuoka,
Luna Izuhara,
Yohta Shimada,
Nobuo Omura,
Hirotaka James Okano,
Takao Ohki,
Takashi Yokoo

Published: July 15, 2014
https://doi.org/10.1371/journal.pone.0102311

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Mesenchymal stem cells
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Hypoxia
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Chronic kidney disease
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Gene expression
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DNA-binding proteins
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Protein expression
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