1H/31P Polarization Transfer at 9.4 Tesla for Improved Specificity of Detecting Phosphomonoesters and Phosphodiesters in Breast Tumor Models

Jannie P. Wijnen; Lu Jiang; Tiffany R. Greenwood; Wybe J. M. van der Kemp; Dennis W. J. Klomp; Kristine Glunde

doi:10.1371/journal.pone.0102256

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Peer-reviewed

Research Article

¹H/³¹P Polarization Transfer at 9.4 Tesla for Improved Specificity of Detecting Phosphomonoesters and Phosphodiesters in Breast Tumor Models

Jannie P. Wijnen ,

Contributed equally to this work with: Jannie P. Wijnen, Lu Jiang

Affiliations Johns Hopkins University In vivo Cellular and Molecular Imaging Center, The Russell H. Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Radiology, University Medical Centre Utrecht, Utrecht, Netherlands
⨯
Lu Jiang ,

Contributed equally to this work with: Jannie P. Wijnen, Lu Jiang

Affiliation Johns Hopkins University In vivo Cellular and Molecular Imaging Center, The Russell H. Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Tiffany R. Greenwood,

Affiliation Johns Hopkins University In vivo Cellular and Molecular Imaging Center, The Russell H. Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Wybe J. M. van der Kemp,

Affiliation Department of Radiology, University Medical Centre Utrecht, Utrecht, Netherlands
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Dennis W. J. Klomp,

Affiliation Department of Radiology, University Medical Centre Utrecht, Utrecht, Netherlands
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Kristine Glunde

* E-mail: kglunde@mri.jhu.edu

Affiliations Johns Hopkins University In vivo Cellular and Molecular Imaging Center, The Russell H. Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Sidney Kimmel Comprehensive Cancer, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

¹H/³¹P Polarization Transfer at 9.4 Tesla for Improved Specificity of Detecting Phosphomonoesters and Phosphodiesters in Breast Tumor Models

Jannie P. Wijnen,
Lu Jiang,
Tiffany R. Greenwood,
Wybe J. M. van der Kemp,
Dennis W. J. Klomp,
Kristine Glunde

Published: July 18, 2014
https://doi.org/10.1371/journal.pone.0102256

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Cancers and neoplasms
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Breast cancer
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Metabolites
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Phospholipids
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Phospholipid signaling cascade
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Relaxation time
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Breast tumors
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