Identification of a Cytotoxic Form of Dimeric Interleukin-2 in Murine Tissues

Lucile E. Wrenshall; Suzanne E. Clabaugh; David R. Cool; Prakash Arumugam; William C. Grunwald; Deandra R. Smith; Gino C. Liu; John D. Miller

doi:10.1371/journal.pone.0102191

Loading metrics

Open Access

Peer-reviewed

Research Article

Identification of a Cytotoxic Form of Dimeric Interleukin-2 in Murine Tissues

Lucile E. Wrenshall ,

* E-mail: lucile.wrenshall@wright.edu

Affiliation Department of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine Wright State University, Dayton, Ohio, United States of America
⨯
Suzanne E. Clabaugh,

Affiliation Department of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine Wright State University, Dayton, Ohio, United States of America
⨯
David R. Cool,

Affiliation Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America
⨯
Prakash Arumugam,

Affiliation Department of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine Wright State University, Dayton, Ohio, United States of America
⨯
William C. Grunwald,

Affiliation Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America
⨯
Deandra R. Smith,

Affiliation Eppley Institute for Cancer Research, University of Nebraska at Omaha, Omaha, Nebraska, United States of America
⨯
Gino C. Liu,

Current address: Advanced Testing Laboratory, Cincinnati, Ohio, United States of America

Affiliation Department of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine Wright State University, Dayton, Ohio, United States of America
⨯
John D. Miller

Affiliation Department of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine Wright State University, Dayton, Ohio, United States of America
⨯

Identification of a Cytotoxic Form of Dimeric Interleukin-2 in Murine Tissues

Lucile E. Wrenshall,
Suzanne E. Clabaugh,
David R. Cool,
Prakash Arumugam,
William C. Grunwald,
Deandra R. Smith,
Gino C. Liu,
John D. Miller

Published: July 14, 2014
https://doi.org/10.1371/journal.pone.0102191

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Cell death
Is the Subject Area "Cell death" applicable to this article?

Thanks for your feedback.
Dimers
Is the Subject Area "Dimers" applicable to this article?

Thanks for your feedback.
Aorta
Is the Subject Area "Aorta" applicable to this article?

Thanks for your feedback.
Cytotoxicity
Is the Subject Area "Cytotoxicity" applicable to this article?

Thanks for your feedback.
Kidneys
Is the Subject Area "Kidneys" applicable to this article?

Thanks for your feedback.
Smooth muscle cells
Is the Subject Area "Smooth muscle cells" applicable to this article?

Thanks for your feedback.
Colorimetric protein concentration assays
Is the Subject Area "Colorimetric protein concentration assays" applicable to this article?

Thanks for your feedback.