Dynamics of Linker Residues Modulate the Nucleic Acid Binding Properties of the HIV-1 Nucleocapsid Protein Zinc Fingers

Loussiné Zargarian; Carine Tisné; Pierre Barraud; Xiaoqian Xu; Nelly Morellet; Brigitte René; Yves Mély; Philippe Fossé; Olivier Mauffret

doi:10.1371/journal.pone.0102150

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Peer-reviewed

Research Article

Dynamics of Linker Residues Modulate the Nucleic Acid Binding Properties of the HIV-1 Nucleocapsid Protein Zinc Fingers

Loussiné Zargarian,

Affiliation Laboratoire de Biologie et Pharmacologie Appliquée, Ecole Normale Supérieure de Cachan, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8113, Cachan, France
⨯
Carine Tisné,

Affiliation Laboratoire de Cristallographie et RMN Biologiques, Université Paris Descartes, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8015, Paris, France
⨯
Pierre Barraud,

Affiliation Laboratoire de Cristallographie et RMN Biologiques, Université Paris Descartes, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8015, Paris, France
⨯
Xiaoqian Xu,

Affiliations Laboratoire de Biologie et Pharmacologie Appliquée, Ecole Normale Supérieure de Cachan, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8113, Cachan, France, Department of Life Sciences, East China Normal University, Shanghai, People's Republic of China
⨯
Nelly Morellet,

Affiliation Centre de Recherches de Gif, Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, Gif sur Yvette, France
⨯
Brigitte René,

Affiliation Laboratoire de Biologie et Pharmacologie Appliquée, Ecole Normale Supérieure de Cachan, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8113, Cachan, France
⨯
Yves Mély,

Affiliation Laboratoire de Biophotonique et Pharmacologie, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7213, Faculté de Pharmacie, Université de Strasbourg, Illkirch, France
⨯
Philippe Fossé,

Affiliation Laboratoire de Biologie et Pharmacologie Appliquée, Ecole Normale Supérieure de Cachan, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8113, Cachan, France
⨯
Olivier Mauffret

* E-mail: olivier.mauffret@lbpa.ens-cachan.fr

Affiliation Laboratoire de Biologie et Pharmacologie Appliquée, Ecole Normale Supérieure de Cachan, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8113, Cachan, France
⨯

Dynamics of Linker Residues Modulate the Nucleic Acid Binding Properties of the HIV-1 Nucleocapsid Protein Zinc Fingers

Loussiné Zargarian,
Carine Tisné,
Pierre Barraud,
Xiaoqian Xu,
Nelly Morellet,
Brigitte René,
Yves Mély,
Philippe Fossé,
Olivier Mauffret

Published: July 16, 2014
https://doi.org/10.1371/journal.pone.0102150

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NMR relaxation
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