Association of Toxicity of Sorafenib and Sunitinib for Human Keratinocytes with Inhibition of Signal Transduction and Activator of Transcription 3 (STAT3)

Kazuhiro Yamamoto; Atsushi Mizumoto; Kohji Nishimura; Atsushi Uda; Akira Mukai; Kazuhiko Yamashita; Manabu Kume; Hiroo Makimoto; Toshinori Bito; Chikako Nishigori; Tsutomu Nakagawa; Takeshi Hirano; Midori Hirai

doi:10.1371/journal.pone.0102110

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Open Access

Peer-reviewed

Research Article

Association of Toxicity of Sorafenib and Sunitinib for Human Keratinocytes with Inhibition of Signal Transduction and Activator of Transcription 3 (STAT3)

Kazuhiro Yamamoto ,

* E-mail: yamakz@med.kobe-u.ac.jp

Affiliation Department of Pharmacy, Kobe University Hospital, Kobe, Japan
⨯
Atsushi Mizumoto,

Affiliation Division of Pharmacokinetics, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Kohji Nishimura,

Affiliation Division of Pharmacokinetics, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Atsushi Uda,

Affiliation Department of Pharmacy, Kobe University Hospital, Kobe, Japan
⨯
Akira Mukai,

Affiliation Department of Pharmacy, Kobe University Hospital, Kobe, Japan
⨯
Kazuhiko Yamashita,

Affiliation Department of Pharmacy, Kobe University Hospital, Kobe, Japan
⨯
Manabu Kume,

Affiliation Department of Pharmacy, Kobe University Hospital, Kobe, Japan
⨯
Hiroo Makimoto,

Affiliation Department of Pharmacy, Kobe University Hospital, Kobe, Japan
⨯
Toshinori Bito,

Affiliation Division of Dermatology, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Chikako Nishigori,

Affiliation Division of Dermatology, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Tsutomu Nakagawa,

Affiliations Department of Pharmacy, Kobe University Hospital, Kobe, Japan, Division of Pharmacokinetics, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Takeshi Hirano,

Affiliations Department of Pharmacy, Kobe University Hospital, Kobe, Japan, Division of Pharmacokinetics, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Midori Hirai

Affiliations Department of Pharmacy, Kobe University Hospital, Kobe, Japan, Division of Pharmacokinetics, Kobe University Graduate School of Medicine, Kobe, Japan
⨯

Association of Toxicity of Sorafenib and Sunitinib for Human Keratinocytes with Inhibition of Signal Transduction and Activator of Transcription 3 (STAT3)

Kazuhiro Yamamoto,
Atsushi Mizumoto,
Kohji Nishimura,
Atsushi Uda,
Akira Mukai,
Kazuhiko Yamashita,
Manabu Kume,
Hiroo Makimoto,
Toshinori Bito,
Chikako Nishigori

Published: July 11, 2014
https://doi.org/10.1371/journal.pone.0102110

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Apoptosis
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Transfection
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Keratinocytes
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Signal inhibition
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Signal transduction
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