Inhibition Mechanism of the Intracellular Transporter Ca2+-Pump from Sarco-Endoplasmic Reticulum by the Antitumor Agent Dimethyl-Celecoxib

Open Access

Peer-reviewed

Research Article

Inhibition Mechanism of the Intracellular Transporter Ca²⁺-Pump from Sarco-Endoplasmic Reticulum by the Antitumor Agent Dimethyl-Celecoxib

Ramón Coca ,

Contributed equally to this work with: Ramón Coca, Fernando Soler

Affiliation Departamento de Medicina Clínica, Universidad Miguel Hernández en Campus de San Juan, Alicante, Spain
⨯
Fernando Soler ,

Contributed equally to this work with: Ramón Coca, Fernando Soler

Affiliation Departamento de Bioquímica y Biología Molecular A, Universidad de Murcia en Campus de Espinardo, Murcia, Spain
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Ernesto Cortés-Castell,

Affiliation Departamento de Farmacología, Pediatría y Química Orgánica, Universidad Miguel Hernández en Campus de San Juan, Alicante, Spain
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Vicente Gil-Guillén,

Affiliation Departamento de Medicina Clínica, Universidad Miguel Hernández en Campus de San Juan, Alicante, Spain
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Francisco Fernández-Belda

* E-mail: fbelda@um.es

Affiliation Departamento de Bioquímica y Biología Molecular A, Universidad de Murcia en Campus de Espinardo, Murcia, Spain
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Vesicles
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Phosphorylation
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Magnesium chloride
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Drug dependence
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Transport inhibition assay
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Apoptosis
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COX-2 inhibitors
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Drug interactions
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