The Melatonin Agonist Ramelteon Induces Duration-Dependent Clock Gene Expression through cAMP Signaling in Pancreatic INS-1 β-Cells

Open Access

Peer-reviewed

Research Article

Keiji Nishiyama,

Affiliation CNS Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan
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Keisuke Hirai

* E-mail: keisuke.hirai@takeda.com

Affiliation CNS Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan
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Melatonin
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Gene expression
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cAMP signaling cascade
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Phosphorylation
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Insulin secretion
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Receptor antagonist therapy
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Glucose
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Polymerase chain reaction
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