Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis

• Bin Li ,

  Contributed equally to this work with: Bin Li, Colin A. Flaveny

  Affiliation Molecular Oncology Program, Department of Surgery, University of Miami, Miami, Florida, United States of America

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• Colin A. Flaveny ,

  Contributed equally to this work with: Bin Li, Colin A. Flaveny

  Affiliation Molecular Oncology Program, Department of Surgery, University of Miami, Miami, Florida, United States of America

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• Camilla Giambelli,

  Affiliation Molecular Oncology Program, Department of Surgery, University of Miami, Miami, Florida, United States of America

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• Dennis Liang Fei,

  Affiliation Molecular Oncology Program, Department of Surgery, University of Miami, Miami, Florida, United States of America

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• Lu Han,

  Affiliation Molecular Oncology Program, Department of Surgery, University of Miami, Miami, Florida, United States of America

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• Brian I. Hang,

  Affiliation Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Feng Bai,

  Affiliation Molecular Oncology Program, Department of Surgery, University of Miami, Miami, Florida, United States of America

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• Xin-Hai Pei,

  Affiliations Molecular Oncology Program, Department of Surgery, University of Miami, Miami, Florida, United States of America, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, United States of America

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• Vania Nose,

  Affiliation Department of Pathology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

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• Oname Burlingame,

  Affiliation Department of Pathology, Jackson Health System, University of Miami, Miami, Florida, United States of America

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• Anthony J. Capobianco,

  Affiliations Molecular Oncology Program, Department of Surgery, University of Miami, Miami, Florida, United States of America, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, United States of America

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• Darren Orton,

  Affiliation Stemsynergy Therapeutics Inc., Miami, Florida, United States of America

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• Ethan Lee,

  Affiliation Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• David J. Robbins

  * E-mail: drobbins@med.miami.edu

  Affiliations Molecular Oncology Program, Department of Surgery, University of Miami, Miami, Florida, United States of America, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, United States of America, Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida, United States of America

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