Dynamically-Driven Enhancement of the Catalytic Machinery of the SARS 3C-Like Protease by the S284-T285-I286/A Mutations on the Extra Domain

Open Access

Peer-reviewed

Research Article

Liangzhong Lim ,

Contributed equally to this work with: Liangzhong Lim, Jiahai Shi

Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Republic of Singapore
⨯
Jiahai Shi ,

Contributed equally to this work with: Liangzhong Lim, Jiahai Shi

Current address: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Republic of Singapore
⨯
Yuguang Mu,

Affiliation School of Biological Sciences, Nanyang Technological University, Singapore, Republic of Singapore
⨯
Jianxing Song

* E-mail: dbssjx@nus.edu.sg

Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Republic of Singapore
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Proteases
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Crystal structure
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SARS
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Dimerization
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Hydrogen bonding
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Catalysis
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Enzymes
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Molecular dynamics
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