System Vaccinology for the Evaluation of Influenza Vaccine Safety by Multiplex Gene Detection of Novel Biomarkers in a Preclinical Study and Batch Release Test

Takuo Mizukami; Haruka Momose; Madoka Kuramitsu; Kazuya Takizawa; Kumiko Araki; Keiko Furuhata; Ken J. Ishii; Isao Hamaguchi; Kazunari Yamaguchi

doi:10.1371/journal.pone.0101835

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Open Access

Peer-reviewed

Research Article

System Vaccinology for the Evaluation of Influenza Vaccine Safety by Multiplex Gene Detection of Novel Biomarkers in a Preclinical Study and Batch Release Test

Takuo Mizukami,

Affiliation Laboratory of Blood and Vaccine safety, Department of Safety Research on Blood and Biologicals, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Haruka Momose,

Affiliation Laboratory of Blood and Vaccine safety, Department of Safety Research on Blood and Biologicals, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Madoka Kuramitsu,

Affiliation Laboratory of Blood and Vaccine safety, Department of Safety Research on Blood and Biologicals, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Kazuya Takizawa,

Affiliation Laboratory of Blood and Vaccine safety, Department of Safety Research on Blood and Biologicals, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Kumiko Araki,

Affiliation Laboratory of Blood and Vaccine safety, Department of Safety Research on Blood and Biologicals, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Keiko Furuhata,

Affiliation Laboratory of Blood and Vaccine safety, Department of Safety Research on Blood and Biologicals, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Ken J. Ishii,

Affiliations Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation (NIBIO), Osaka, Japan, Laboratory of Vaccine Science, WPI Immunology Frontier Research Center (WPI-IFREC), Osaka University, Osaka, Japan
⨯
Isao Hamaguchi ,

* E-mail: 130hama@nih.go.jp

Affiliation Laboratory of Blood and Vaccine safety, Department of Safety Research on Blood and Biologicals, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Kazunari Yamaguchi

Affiliation Laboratory of Blood and Vaccine safety, Department of Safety Research on Blood and Biologicals, National Institute of Infectious Diseases, Tokyo, Japan
⨯

System Vaccinology for the Evaluation of Influenza Vaccine Safety by Multiplex Gene Detection of Novel Biomarkers in a Preclinical Study and Batch Release Test

Takuo Mizukami,
Haruka Momose,
Madoka Kuramitsu,
Kazuya Takizawa,
Kumiko Araki,
Keiko Furuhata,
Ken J. Ishii,
Isao Hamaguchi,
Kazunari Yamaguchi

Published: July 10, 2014
https://doi.org/10.1371/journal.pone.0101835

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