Validation of a LC-MS/MS Method for Quantifying Urinary Nicotine, Six Nicotine Metabolites and the Minor Tobacco Alkaloids—Anatabine and Anabasine—in Smokers' Urine

James E. McGuffey; Binnian Wei; John T. Bernert; John C. Morrow; Baoyun Xia; Lanqing Wang; Benjamin C. Blount

doi:10.1371/journal.pone.0101816

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Peer-reviewed

Research Article

Validation of a LC-MS/MS Method for Quantifying Urinary Nicotine, Six Nicotine Metabolites and the Minor Tobacco Alkaloids—Anatabine and Anabasine—in Smokers' Urine

James E. McGuffey ,

* E-mail: jem4@cdc.gov

Affiliation Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Binnian Wei,

Affiliation Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
John T. Bernert,

Affiliation Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
John C. Morrow,

Affiliation Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Baoyun Xia,

Affiliation Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Lanqing Wang,

Affiliation Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Benjamin C. Blount

Affiliation Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯

Validation of a LC-MS/MS Method for Quantifying Urinary Nicotine, Six Nicotine Metabolites and the Minor Tobacco Alkaloids—Anatabine and Anabasine—in Smokers' Urine

James E. McGuffey,
Binnian Wei,
John T. Bernert,
John C. Morrow,
Baoyun Xia,
Lanqing Wang,
Benjamin C. Blount

Published: July 11, 2014
https://doi.org/10.1371/journal.pone.0101816

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