Genetic Inhibition of Phosphorylation of the Translation Initiation Factor eIF2α Does Not Block Aβ-Dependent Elevation of BACE1 and APP Levels or Reduce Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

Open Access

Peer-reviewed

Research Article

Katherine R. Sadleir,

Affiliation Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America
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William A. Eimer,

Affiliation Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
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Randal J. Kaufman,

Affiliation Sanford|Burnham Medical Research Institute, La Jolla, California, United States of America
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Pavel Osten,

Affiliation Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
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Robert Vassar

* E-mail: r-vassar@northwestern.edu

Affiliation Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America
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Phosphorylation
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Neurons
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Mouse models
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Genetically modified animals
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Hippocampus
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Oligomers
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Messenger RNA
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Protein translation
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