Characterization of a Novel BCHE “Silent” Allele: Point Mutation (p.Val204Asp) Causes Loss of Activity and Prolonged Apnea with Suxamethonium

• Herve Delacour ,

  * E-mail: herve.delacour@santarm.fr

  Affiliation Bégin Military Teaching Hospital, Department of Biology, Unit of Human Genetics, Saint Mandé, France

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• Sofya Lushchekina,

  Affiliation Modeling of Biomolecules Lab., N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia

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• Isabelle Mabboux,

  Affiliation Bégin Military Teaching Hospital, Department of Biology, Unit of Human Genetics, Saint Mandé, France

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• Aurore Bousquet,

  Affiliations Bégin Military Teaching Hospital, Department of Biology, Unit of Human Genetics, Saint Mandé, France, Val de Grace Military Medical School, Paris, France

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• Franck Ceppa,

  Affiliations Bégin Military Teaching Hospital, Department of Biology, Unit of Human Genetics, Saint Mandé, France, Val de Grace Military Medical School, Paris, France

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• Lawrence M. Schopfer,

  Affiliation Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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• Oksana Lockridge,

  Affiliation Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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• Patrick Masson

  Affiliations Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, DYNAMOP, Institut de Biologie Structurale, Grenoble, France

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